The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Signal transducer and activator of transcription (STAT) proteins communicate from cell-surface receptors to drive transcription of immune response genes. The parasite Toxoplasma gondii blocks STAT1-mediated gene expression by secreting the intrinsically disordered protein TgIST that traffics to the...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 13; číslo 1; s. 4047 - 15
Hlavní autoři:	Huang, Zhou, Liu, Hejun, Nix, Jay, Xu, Rui, Knoverek, Catherine R., Bowman, Gregory R., Amarasinghe, Gaya K., Sibley, L. David
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 13.07.2022 Nature Publishing Group Nature Portfolio
Témata:	101/58 13/109 13/31 14/5 631/250/2499 631/250/516 631/326/417/2547 631/535/1266 82/103 9/10 Antimicrobial responses BASIC BIOLOGICAL SCIENCES Binding Blocking Cell surface Cellular structure Dimerization Dimers Gene expression Genes Grooves Humanities and Social Sciences Immune response Immune system Interferon Interferon-gamma - metabolism Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism multidisciplinary Parasite immune evasion Parasites Phosphorylation Proteins Recruitment Science Science (multidisciplinary) Signal Transduction src Homology Domains Stat1 protein STAT1 Transcription Factor - metabolism Toxoplasma Toxoplasma gondii Transcription Transcription factors X-ray crystallography
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!