Comparative Evaluation of Existing and Rationally Designed Novel Antimicrobial Peptides for Treatment of Skin and Soft Tissue Infections

Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) can range in severi...

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Vydané v:Antibiotics (Basel) Ročník 12; číslo 3; s. 551
Hlavní autori: Ramata-Stunda, Anna, Boroduskis, Martins, Kaktina, Elza, Patetko, Liene, Kalnenieks, Uldis, Lasa, Zane, Rubina, Marta, Strazdina, Inese, Kalnins, Gints, Rutkis, Reinis
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.03.2023
MDPI
Predmet:
Abscesses
Acinetobacter baumannii
Acne
Antibacterial activity
Antibacterial agents
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Bacteria
Bacterial infections
Care and treatment
Comparative analysis
Cutibacterium acnes
Cytokines
Cytotoxicity
Dermatologic agents
Dermatology
Drug resistance
Drug resistance in microorganisms
E coli
Enterobacter
Enterococcus faecium
Escherichia coli
Fibroblasts
Formulae, receipts, prescriptions
Gram-positive bacteria
Health aspects
Infection
Infections
Interleukin 10
Klebsiella
Klebsiella pneumoniae
Leukocytes (mononuclear)
Microorganisms
Minimum inhibitory concentration
Pathogenesis
Pathogens
Peptides
Peripheral blood mononuclear cells
Primary care
Pseudomonas aeruginosa
Scientific equipment and supplies industry
Skin
Skin diseases
skin pathogens
Soft tissues
Staphylococcus aureus
Staphylococcus aureus infections
Toxicity
Tumor necrosis factor-α
United Kingdom
Switzerland
Latvia
acne
skin pathogens
antimicrobial peptides
cytotoxicity
ISSN:2079-6382, 2079-6382
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Abstract Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) can range in severity, and treating them is becoming increasingly challenging due to the growing number of antibiotic-resistant pathogens. There is also a rise in antibiotic-resistant strains of Cutibacterium acne, which plays a role in the development of acne. Antimicrobial peptides (AMPs) are considered to be a promising solution to the challenges posed by antibiotic resistance. In this study, six new AMPs were rationally designed and compared to five existing peptides. The MIC values against E. coli, P. aeruginosa, K. pneumoniae, E. faecium, S. aureus, and C. acnes were determined, and the peptides were evaluated for cytotoxicity using Balb/c 3T3 cells and dermal fibroblasts, as well as for hemolytic activity. The interaction with bacterial membranes and the effect on TNF-α and IL-10 secretion were also evaluated for selected peptides. Of the tested peptides, RP556 showed high broad-spectrum antibacterial activity without inducing cytotoxicity or hemolysis, and it stimulated the production of IL-10 in LPS-stimulated peripheral blood mononuclear cells. Four of the novel AMPs showed pronounced specificity against C. acnes, with MIC values (0.3–0.5 μg/mL) below the concentrations that were cytotoxic or hemolytic.
AbstractList Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) can range in severity, and treating them is becoming increasingly challenging due to the growing number of antibiotic-resistant pathogens. There is also a rise in antibiotic-resistant strains of Cutibacterium acne, which plays a role in the development of acne. Antimicrobial peptides (AMPs) are considered to be a promising solution to the challenges posed by antibiotic resistance. In this study, six new AMPs were rationally designed and compared to five existing peptides. The MIC values against E. coli, P. aeruginosa, K. pneumoniae, E. faecium, S. aureus, and C. acnes were determined, and the peptides were evaluated for cytotoxicity using Balb/c 3T3 cells and dermal fibroblasts, as well as for hemolytic activity. The interaction with bacterial membranes and the effect on TNF-α and IL-10 secretion were also evaluated for selected peptides. Of the tested peptides, RP556 showed high broad-spectrum antibacterial activity without inducing cytotoxicity or hemolysis, and it stimulated the production of IL-10 in LPS-stimulated peripheral blood mononuclear cells. Four of the novel AMPs showed pronounced specificity against C. acnes, with MIC values (0.3-0.5 μg/mL) below the concentrations that were cytotoxic or hemolytic.
Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens ( , , , , , and sp.) can range in severity, and treating them is becoming increasingly challenging due to the growing number of antibiotic-resistant pathogens. There is also a rise in antibiotic-resistant strains of , which plays a role in the development of acne. Antimicrobial peptides (AMPs) are considered to be a promising solution to the challenges posed by antibiotic resistance. In this study, six new AMPs were rationally designed and compared to five existing peptides. The MIC values against , , , , , and were determined, and the peptides were evaluated for cytotoxicity using Balb/c 3T3 cells and dermal fibroblasts, as well as for hemolytic activity. The interaction with bacterial membranes and the effect on TNF-α and IL-10 secretion were also evaluated for selected peptides. Of the tested peptides, RP556 showed high broad-spectrum antibacterial activity without inducing cytotoxicity or hemolysis, and it stimulated the production of IL-10 in LPS-stimulated peripheral blood mononuclear cells. Four of the novel AMPs showed pronounced specificity against , with MIC values (0.3-0.5 μg/mL) below the concentrations that were cytotoxic or hemolytic.
Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) can range in severity, and treating them is becoming increasingly challenging due to the growing number of antibiotic-resistant pathogens. There is also a rise in antibiotic-resistant strains of Cutibacterium acne, which plays a role in the development of acne. Antimicrobial peptides (AMPs) are considered to be a promising solution to the challenges posed by antibiotic resistance. In this study, six new AMPs were rationally designed and compared to five existing peptides. The MIC values against E. coli, P. aeruginosa, K. pneumoniae, E. faecium, S. aureus, and C. acnes were determined, and the peptides were evaluated for cytotoxicity using Balb/c 3T3 cells and dermal fibroblasts, as well as for hemolytic activity. The interaction with bacterial membranes and the effect on TNF-α and IL-10 secretion were also evaluated for selected peptides. Of the tested peptides, RP556 showed high broad-spectrum antibacterial activity without inducing cytotoxicity or hemolysis, and it stimulated the production of IL-10 in LPS-stimulated peripheral blood mononuclear cells. Four of the novel AMPs showed pronounced specificity against C. acnes, with MIC values (0.3-0.5 μg/mL) below the concentrations that were cytotoxic or hemolytic.Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.) can range in severity, and treating them is becoming increasingly challenging due to the growing number of antibiotic-resistant pathogens. There is also a rise in antibiotic-resistant strains of Cutibacterium acne, which plays a role in the development of acne. Antimicrobial peptides (AMPs) are considered to be a promising solution to the challenges posed by antibiotic resistance. In this study, six new AMPs were rationally designed and compared to five existing peptides. The MIC values against E. coli, P. aeruginosa, K. pneumoniae, E. faecium, S. aureus, and C. acnes were determined, and the peptides were evaluated for cytotoxicity using Balb/c 3T3 cells and dermal fibroblasts, as well as for hemolytic activity. The interaction with bacterial membranes and the effect on TNF-α and IL-10 secretion were also evaluated for selected peptides. Of the tested peptides, RP556 showed high broad-spectrum antibacterial activity without inducing cytotoxicity or hemolysis, and it stimulated the production of IL-10 in LPS-stimulated peripheral blood mononuclear cells. Four of the novel AMPs showed pronounced specificity against C. acnes, with MIC values (0.3-0.5 μg/mL) below the concentrations that were cytotoxic or hemolytic.
Audience Academic
Author Boroduskis, Martins
Strazdina, Inese
Rutkis, Reinis
Ramata-Stunda, Anna
Lasa, Zane
Kaktina, Elza
Patetko, Liene
Kalnins, Gints
Rubina, Marta
Kalnenieks, Uldis
AuthorAffiliation 4 Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., LV-1067 Riga, Latvia
2 Laboratory of Bioanalytical and Biodosimetry Methods, Faculty of Biology, University of Latvia, 3 Jelgavas Str., LV-1004 Riga, Latvia
1 Alternative Plants Ltd., 2 Podraga Str., LV-1007 Riga, Latvia
3 Institute of Microbiology and Biotechnology, University of Latvia, 1 Jelgavas Str., LV-1004 Riga, Latvia
AuthorAffiliation_xml – name: 1 Alternative Plants Ltd., 2 Podraga Str., LV-1007 Riga, Latvia
– name: 3 Institute of Microbiology and Biotechnology, University of Latvia, 1 Jelgavas Str., LV-1004 Riga, Latvia
– name: 2 Laboratory of Bioanalytical and Biodosimetry Methods, Faculty of Biology, University of Latvia, 3 Jelgavas Str., LV-1004 Riga, Latvia
– name: 4 Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., LV-1067 Riga, Latvia
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36978418$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1016_j_peptides_2025_171440
crossref_primary_10_3390_ijms252312484
crossref_primary_10_3390_pharmaceutics16121542
crossref_primary_10_1128_spectrum_02523_24
crossref_primary_10_3390_antibiotics13050451
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Keywords acne
skin pathogens
antimicrobial peptides
cytotoxicity
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Snippet Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus...
Skin and soft tissue infections (SSTIs) and acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens ( , , , , , and...
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SubjectTerms Abscesses
Acinetobacter baumannii
Acne
Antibacterial activity
Antibacterial agents
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Bacteria
Bacterial infections
Care and treatment
Comparative analysis
Cutibacterium acnes
Cytokines
Cytotoxicity
Dermatologic agents
Dermatology
Drug resistance
Drug resistance in microorganisms
E coli
Enterobacter
Enterococcus faecium
Escherichia coli
Fibroblasts
Formulae, receipts, prescriptions
Gram-positive bacteria
Health aspects
Infection
Infections
Interleukin 10
Klebsiella
Klebsiella pneumoniae
Leukocytes (mononuclear)
Microorganisms
Minimum inhibitory concentration
Pathogenesis
Pathogens
Peptides
Peripheral blood mononuclear cells
Primary care
Pseudomonas aeruginosa
Scientific equipment and supplies industry
Skin
Skin diseases
skin pathogens
Soft tissues
Staphylococcus aureus
Staphylococcus aureus infections
Toxicity
Tumor necrosis factor-α
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Title Comparative Evaluation of Existing and Rationally Designed Novel Antimicrobial Peptides for Treatment of Skin and Soft Tissue Infections
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