JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose tissue, is a devastating complication of cancer and other chronic diseases. Interleukin-6 and related cytokines are associated with muscle wasting in clinical and experimental cachexia, although the mechanisms by w...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism Jg. 303; H. 3; S. E410
Hauptverfasser:	Bonetto, Andrea, Aydogdu, Tufan, Jin, Xiaoling, Zhang, Zongxiu, Zhan, Rui, Puzis, Leopold, Koniaris, Leonidas G, Zimmers, Teresa A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2012
Schlagworte:	Animals Cachexia - etiology Cachexia - genetics Cachexia - pathology Cachexia - prevention & control Cells, Cultured CHO Cells Cricetinae Cricetulus Disease Models, Animal Female Interleukin-6 - genetics Interleukin-6 - metabolism Interleukin-6 - physiology Janus Kinases - antagonists & inhibitors Janus Kinases - genetics Janus Kinases - metabolism Male Mice Mice, Inbred C57BL Mice, Nude Mice, Transgenic Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Mutant Proteins - administration & dosage Mutant Proteins - genetics Neoplasms - complications Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Pyrazoles - administration & dosage Pyrazoles - pharmacology RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacology Signal Transduction - drug effects Signal Transduction - genetics STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Wasting Syndrome - genetics Wasting Syndrome - metabolism Wasting Syndrome - pathology Wasting Syndrome - prevention & control
ISSN:	1522-1555, 1522-1555
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