Dietary vitamin B6 intake modulates colonic inflammation in the IL10−/− model of inflammatory bowel disease

Pyridoxal-5-phosphate, the biologically active form of vitamin B6, is a cofactor for over 140 biochemical reactions. Although severe vitamin B6 deficiency is rare, mild inadequacy [plasma pyridoxal 5’-phosphate (PLP) <20 nmol/L] is observed in 19–27% of the US population. Plasma PLP concentration...

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Bibliographic Details
Published in:	The Journal of nutritional biochemistry Vol. 24; no. 12; pp. 2138 - 2143
Main Authors:	Selhub, Jacob, Byun, Alexander, Liu, Zhenhua, Mason, Joel B., Bronson, Roderick T., Crott, Jimmy W.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2013
Subjects:	Animals Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism chemical reactions chemotaxis Colitis Colon Colon - drug effects Colon - physiopathology Cyclooxygenase 2 - metabolism diet Dietary Supplements Disease Models, Animal Female genetic markers Helicobacter hepaticus Inflammation inflammatory bowel disease Inflammatory Bowel Diseases - drug therapy interferon-gamma Interferon-gamma - metabolism Interleukin-10 - metabolism interleukin-6 Interleukin-6 - metabolism Lysophospholipids - metabolism Male Mice Mice, Knockout Nitric Oxide Synthase Type II - metabolism pyridoxal Pyridoxal 5’ phosphate pyridoxine Shingosine 1 phosphate sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism United States Vitamin B 6 - administration & dosage Vitamin B 6 - blood weanlings United States S1P PLP Pyridoxal 5’ phosphate IBD Inflammation Colitis Colon Shingosine 1 phosphate Inflammatory bowel disease Pyridoxal 5’-phosphate Sphingosine 1-phosphate
ISSN:	0955-2863, 1873-4847, 1873-4847
Online Access:	Get full text
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