Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study
Background Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibilit...
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| Vydané v: | BMC neurology Ročník 13; číslo 1; s. 173 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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London
BioMed Central
13.11.2013
BioMed Central Ltd Springer Nature B.V |
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| ISSN: | 1471-2377, 1471-2377 |
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| Abstract | Background
Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS.
Methods
A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression.
Results
The mean number of T2 lesions was 24.30 ± 19.68 (range:1–113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0–32). Individual lesion size ranged from 14.31 to 55750.60 mm
3
. Non-white subjects had higher T2–LV (unadjusted p
T2-LV
= 0.028; adjusted p
T2-LV
= 0.044), and maximal individual T2-LV (unadjusted p
Max
= 0.007; adjusted p
Max
= 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07).
Conclusion
Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. |
|---|---|
| AbstractList | Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods: A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results: The mean number of T2 lesions was 24.30 plus or minus 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 plus or minus 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm super(3). Non-white subjects had higher T2-LV (unadjusted p sub(T2-LV) = 0.028; adjusted p sub(T2-LV) = 0.044), and maximal individual T2-LV (unadjusted p sub(Max) = 0.007; adjusted p sub(Max) = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07). Conclusion: Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS.BACKGROUNDPediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS.A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression.METHODSA common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression.The mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3. Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07).RESULTSThe mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3. Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07).Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS.CONCLUSIONAssessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. The mean number of T2 lesions was 24.30 [+ or -] 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 [+ or -] 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm.sup.3. Non-white subjects had higher T2-LV (unadjusted p.sub.T2-LV = 0.028; adjusted p.sub.T2-LV = 0.044), and maximal individual T2-LV (unadjusted p.sub.Max = 0.007; adjusted p.sub.Max = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07). Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. Doc number: 173 Abstract Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods: A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results: The mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3 . Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07). Conclusion: Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. Background Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results The mean number of T2 lesions was 24.30 [+ or -] 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 [+ or -] 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm.sup.3. Non-white subjects had higher T2-LV (unadjusted p.sub.T2-LV = 0.028; adjusted p.sub.T2-LV = 0.044), and maximal individual T2-LV (unadjusted p.sub.Max = 0.007; adjusted p.sub.Max = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07). Conclusion Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. The mean number of T2 lesions was 24.30 ± 19.68 (range:1-113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0-32). Individual lesion size ranged from 14.31 to 55750.60 mm3. Non-white subjects had higher T2-LV (unadjusted pT2-LV = 0.028; adjusted pT2-LV = 0.044), and maximal individual T2-LV (unadjusted pMax = 0.007; adjusted pMax = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07). Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. Background Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3 years of disease onset, examination within 1 month of MRI and no steroids 1 month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results The mean number of T2 lesions was 24.30 ± 19.68 (range:1–113) and mean gadolinium-enhancing lesion count was 1.85 ± 5.84, (range:0–32). Individual lesion size ranged from 14.31 to 55750.60 mm 3 . Non-white subjects had higher T2–LV (unadjusted p T2-LV = 0.028; adjusted p T2-LV = 0.044), and maximal individual T2-LV (unadjusted p Max = 0.007; adjusted p Max = 0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p = 0.07). Conclusion Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS. |
| ArticleNumber | 173 |
| Audience | Academic |
| Author | Yeh, Ann Kuntz, Nancy Chitnis, Tanuja Pelletier, Daniel Healy, Brian C Chabas, Dorothee Strober, Jonathan B Waubant, Emmanuelle Krupp, Lauren Zivadinov, Robert Ness, Jayne Gorman, Mark P Erickson, Bradley Weinstock-Guttman, Bianca Musallam, Alexander Guttmann, Charles R Rodriguez, Moses Zaitsev, Alexander Bergsland, Niels |
| AuthorAffiliation | 8 Department of Neurology, University of California, San Francisco, USA 1 Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, 55 Fruit St, ACC 708, 02114 Boston, MA, USA 7 Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA 6 Department of Pediatric Neurology, University of Alabama, Birmingham, AL, USA 4 Department of Neurology and Immunology, Rochester, MN, USA 9 Department of Neurology, SUNY-Stonybrook, Stonybrook, NY, USA 10 Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, SUNY-Buffalo, Buffalo, USA 5 Department of Radiology, Mayo Clinic, Rochester, MN, USA 3 The Pediatric MS Center at the Jacobs Neurological Institute, SUNY-Buffalo, Buffalo NY, USA 2 Center for Neurological Imaging, Brigham and Women’s Hospital, Boston, MA, USA 11 Department of Pediatrics Mayo Clinic, Rochester, MN, USA |
| AuthorAffiliation_xml | – name: 10 Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, SUNY-Buffalo, Buffalo, USA – name: 11 Department of Pediatrics Mayo Clinic, Rochester, MN, USA – name: 2 Center for Neurological Imaging, Brigham and Women’s Hospital, Boston, MA, USA – name: 6 Department of Pediatric Neurology, University of Alabama, Birmingham, AL, USA – name: 3 The Pediatric MS Center at the Jacobs Neurological Institute, SUNY-Buffalo, Buffalo NY, USA – name: 9 Department of Neurology, SUNY-Stonybrook, Stonybrook, NY, USA – name: 5 Department of Radiology, Mayo Clinic, Rochester, MN, USA – name: 7 Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA – name: 4 Department of Neurology and Immunology, Rochester, MN, USA – name: 8 Department of Neurology, University of California, San Francisco, USA – name: 1 Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, 55 Fruit St, ACC 708, 02114 Boston, MA, USA |
| Author_xml | – sequence: 1 givenname: Tanuja surname: Chitnis fullname: Chitnis, Tanuja email: tchitnis@rics.bwh.harvard.edu organization: Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children – sequence: 2 givenname: Charles R surname: Guttmann fullname: Guttmann, Charles R organization: Center for Neurological Imaging, Brigham and Women’s Hospital – sequence: 3 givenname: Alexander surname: Zaitsev fullname: Zaitsev, Alexander organization: Center for Neurological Imaging, Brigham and Women’s Hospital – sequence: 4 givenname: Alexander surname: Musallam fullname: Musallam, Alexander organization: Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children – sequence: 5 givenname: Bianca surname: Weinstock-Guttman fullname: Weinstock-Guttman, Bianca organization: The Pediatric MS Center at the Jacobs Neurological Institute, SUNY-Buffalo – sequence: 6 givenname: Ann surname: Yeh fullname: Yeh, Ann organization: The Pediatric MS Center at the Jacobs Neurological Institute, SUNY-Buffalo – sequence: 7 givenname: Moses surname: Rodriguez fullname: Rodriguez, Moses organization: Department of Neurology and Immunology – sequence: 8 givenname: Jayne surname: Ness fullname: Ness, Jayne organization: Department of Pediatric Neurology, University of Alabama – sequence: 9 givenname: Mark P surname: Gorman fullname: Gorman, Mark P organization: Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children – sequence: 10 givenname: Brian C surname: Healy fullname: Healy, Brian C organization: Biostatistics Center, Massachusetts General Hospital – sequence: 11 givenname: Nancy surname: Kuntz fullname: Kuntz, Nancy organization: Department of Pediatrics Mayo Clinic – sequence: 12 givenname: Dorothee surname: Chabas fullname: Chabas, Dorothee organization: Department of Neurology, University of California – sequence: 13 givenname: Jonathan B surname: Strober fullname: Strober, Jonathan B organization: Department of Neurology, University of California – sequence: 14 givenname: Emmanuelle surname: Waubant fullname: Waubant, Emmanuelle organization: Department of Neurology, University of California – sequence: 15 givenname: Lauren surname: Krupp fullname: Krupp, Lauren organization: Department of Neurology, SUNY-Stonybrook – sequence: 16 givenname: Daniel surname: Pelletier fullname: Pelletier, Daniel organization: Department of Neurology, University of California – sequence: 17 givenname: Bradley surname: Erickson fullname: Erickson, Bradley organization: Department of Radiology, Mayo Clinic – sequence: 18 givenname: Niels surname: Bergsland fullname: Bergsland, Niels organization: Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, SUNY-Buffalo – sequence: 19 givenname: Robert surname: Zivadinov fullname: Zivadinov, Robert organization: Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, SUNY-Buffalo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24225378$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fneur_2023_1215774 crossref_primary_10_1002_hbm_26106 crossref_primary_10_1016_S1474_4422_14_70093_6 crossref_primary_10_1212_WNL_0000000000210140 crossref_primary_10_1002_mrm_27927 |
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| Copyright | Chitnis et al.; licensee BioMed Central Ltd. 2013 COPYRIGHT 2013 BioMed Central Ltd. 2013 Chitnis et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2013 Chitnis et al.; licensee BioMed Central Ltd. 2013 Chitnis et al.; licensee BioMed Central Ltd. |
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| Keywords | Multiple Sclerosis Lesion Volume Lesion Number EDSS Score Pediatric Multiple Sclerosis |
| Language | English |
| License | http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights,... Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however... Background Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights,... Doc number: 173 Abstract Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may... Background: Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights,... |
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| SubjectTerms | Adolescent Child Child, Preschool Children Demyelinating diseases Diagnosis Disabled Persons Feasibility Studies Female Health aspects Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Multiple sclerosis Multiple Sclerosis - diagnosis Neurochemistry Neurology Neurosurgery Pilot Projects Research Article United States |
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