Protein C anticoagulant system—anti-inflammatory effects

Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on...

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Vydané v:	Seminars in immunopathology Ročník 34; číslo 1; s. 127 - 132
Hlavný autor:	Esmon, Charles T.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer-Verlag 01.01.2012 Springer Nature B.V
Predmet:	Animals Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - metabolism Anticoagulants Anticoagulants - immunology Anticoagulants - metabolism Antigens, CD - biosynthesis Antigens, CD - immunology Biomedical and Life Sciences Biomedicine CD11b Antigen - biosynthesis CD11b Antigen - immunology Cytokines Down-Regulation - immunology E coli Endothelial Protein C Receptor Endothelium Humans Immunology Inflammation Internal Medicine Leukocytes Protein C - immunology Protein C - metabolism Proteins Receptor, PAR-1 - biosynthesis Receptor, PAR-1 - immunology Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - immunology Review Sepsis Signal Transduction - immunology Thrombosis Thrombosis - blood Thrombosis - immunology Thrombosis - therapy United States > US Oklahoma Histones Thrombin Sepsis Inflammation Thrombomodulin Reperfusion injury
ISSN:	1863-2297, 1863-2300, 1863-2300
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Shrnutí:	Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1863-2297 1863-2300 1863-2300
DOI:	10.1007/s00281-011-0284-6