Protein C anticoagulant system—anti-inflammatory effects

Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on...

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Veröffentlicht in:Seminars in immunopathology Jg. 34; H. 1; S. 127 - 132
1. Verfasser: Esmon, Charles T.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer-Verlag 01.01.2012
Springer Nature B.V
Schlagworte:
Animals
Anti-Inflammatory Agents - immunology
Anti-Inflammatory Agents - metabolism
Anticoagulants
Anticoagulants - immunology
Anticoagulants - metabolism
Antigens, CD - biosynthesis
Antigens, CD - immunology
Biomedical and Life Sciences
Biomedicine
CD11b Antigen - biosynthesis
CD11b Antigen - immunology
Cytokines
Down-Regulation - immunology
E coli
Endothelial Protein C Receptor
Endothelium
Humans
Immunology
Inflammation
Internal Medicine
Leukocytes
Protein C - immunology
Protein C - metabolism
Proteins
Receptor, PAR-1 - biosynthesis
Receptor, PAR-1 - immunology
Receptors, Cell Surface - biosynthesis
Receptors, Cell Surface - immunology
Review
Sepsis
Signal Transduction - immunology
Thrombosis
Thrombosis - blood
Thrombosis - immunology
Thrombosis - therapy
United States > US
Oklahoma
Histones
Thrombin
Sepsis
Inflammation
Thrombomodulin
Reperfusion injury
ISSN:1863-2297, 1863-2300, 1863-2300
Online-Zugang:Volltext
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Zusammenfassung:Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease.
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ISSN:1863-2297
1863-2300
1863-2300
DOI:10.1007/s00281-011-0284-6