Protein C anticoagulant system—anti-inflammatory effects

Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on...

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Veröffentlicht in:	Seminars in immunopathology Jg. 34; H. 1; S. 127 - 132
1. Verfasser:	Esmon, Charles T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer-Verlag 01.01.2012 Springer Nature B.V
Schlagworte:	Animals Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - metabolism Anticoagulants Anticoagulants - immunology Anticoagulants - metabolism Antigens, CD - biosynthesis Antigens, CD - immunology Biomedical and Life Sciences Biomedicine CD11b Antigen - biosynthesis CD11b Antigen - immunology Cytokines Down-Regulation - immunology E coli Endothelial Protein C Receptor Endothelium Humans Immunology Inflammation Internal Medicine Leukocytes Protein C - immunology Protein C - metabolism Proteins Receptor, PAR-1 - biosynthesis Receptor, PAR-1 - immunology Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - immunology Review Sepsis Signal Transduction - immunology Thrombosis Thrombosis - blood Thrombosis - immunology Thrombosis - therapy United States > US Oklahoma Histones Thrombin Sepsis Inflammation Thrombomodulin Reperfusion injury
ISSN:	1863-2297, 1863-2300, 1863-2300
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Abstract	Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease.
AbstractList	Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease. Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease.Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease. Issue Title: Coagulation and Inflammation Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct anticoagulant activity which is likely augmented by its cytoprotective activity, thereby limiting exposure of procoagulant cellular membrane surfaces on cells. Beyond that, the pathway signals the cells to prevent apoptosis, to dampen inflammation, to increase endothelial barrier function, and to selectively downregulate some genes implicated in disease progression. Most of these functions are manifested to APC binding to endothelial protein C receptor (EPCR) allowing PAR1 activation, but activation of other PARS is also implicated in some cases. In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease.[PUBLICATION ABSTRACT]
Author	Esmon, Charles T.
Author_xml	– sequence: 1 givenname: Charles T. surname: Esmon fullname: Esmon, Charles T. email: esmonc@omrf.org organization: Laboratory of Coagulation Biology, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute at OMRF, Departments of Pathology & Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/21822632$$D View this record in MEDLINE/PubMed
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Keywords	Histones Thrombin Sepsis Inflammation Thrombomodulin Reperfusion injury
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Snippet	Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct... Issue Title: Coagulation and Inflammation Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These...
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SubjectTerms	Animals Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - metabolism Anticoagulants Anticoagulants - immunology Anticoagulants - metabolism Antigens, CD - biosynthesis Antigens, CD - immunology Biomedical and Life Sciences Biomedicine CD11b Antigen - biosynthesis CD11b Antigen - immunology Cytokines Down-Regulation - immunology E coli Endothelial Protein C Receptor Endothelium Humans Immunology Inflammation Internal Medicine Leukocytes Protein C - immunology Protein C - metabolism Proteins Receptor, PAR-1 - biosynthesis Receptor, PAR-1 - immunology Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - immunology Review Sepsis Signal Transduction - immunology Thrombosis Thrombosis - blood Thrombosis - immunology Thrombosis - therapy
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Title	Protein C anticoagulant system—anti-inflammatory effects
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