Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

Alzheimer's disease (AD) prevalence is increasing, but its etiology remains elusive. Gut microbes can contribute to AD pathology and may help identifying novel markers and therapies against AD. Herein, we examine how the gut microbiome differs in older adults with mild cognitive impairment comp...

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Veröffentlicht in:	EBioMedicine Jg. 47; S. 529 - 542
Hauptverfasser:	Nagpal, Ravinder, Neth, Bryan J., Wang, Shaohua, Craft, Suzanne, Yadav, Hariom
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.09.2019 Elsevier
Schlagworte:	Advanced Basic Science Aged Alzheimer Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - psychology Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism Biomarkers Cognitive Dysfunction Dementia Diet Diet, Ketogenic Diet, Mediterranean Fatty Acids, Volatile - metabolism Female Gastrointestinal Microbiome High fat Humans Internal Medicine Ketogenic Male Microbiota Middle Aged Nutrition Research paper Short-chain fatty acids Short-chain fatty acids Lefse Aß40/42 AD FFAR 2/3 Nutrition OTUs LDA CN Alzheimer Ketogenic LPS Microbiota MCI Diet High fat AHAD PD ApoE ε-4 KD SCFAs MMKD Dementia apolipoprotein-E ε-4 allele LDA effect size modified Mediterranean ketogenic diet ketogenic diet phylogenetic diversity American Heart Association Diet Alzheimer's disease linear discrimination analysis mildly cognitive impaired free fatty acid receptor 2/3 amyloid ß40/42 operational taxonomic units cognitively normal lipopolysaccharide
ISSN:	2352-3964, 2352-3964
Online-Zugang:	Volltext
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