Plasma protein binding prediction focusing on residue-level features and circularity of cyclic peptides by deep learning

Abstract Motivation In recent years, cyclic peptide drugs have been receiving increasing attention because they can target proteins that are difficult to be tackled by conventional small-molecule drugs or antibody drugs. Plasma protein binding rate (%PPB) is a significant pharmacokinetic property of...

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Vydané v:	Bioinformatics Ročník 38; číslo 4; s. 1110 - 1117
Hlavní autori:	Li, Jianan, Yanagisawa, Keisuke, Yoshikawa, Yasushi, Ohue, Masahito, Akiyama, Yutaka
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 27.01.2022
Predmet:	Blood Proteins Deep Learning Original Papers Peptides, Cyclic Protein Binding Software
ISSN:	1367-4803, 1367-4811, 1460-2059, 1367-4811
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