Clinical significance of residual viremia detected by two real-time PCR assays for response-guided therapy of HCV genotype 1 infection

The duration of current standard dual and protease inhibitor-based triple therapies for chronic hepatitis C is determined by assessment of early viral kinetics. Little is known about differences between HCV RNA assays for the use in response guided therapy. HCV RNA was assessed by two widely used re...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 60; no. 5; pp. 913 - 919
Main Authors:	Vermehren, Johannes, Aghemo, Alessio, Falconer, Karolin, Susser, Simone, Lunghi, Giovanna, Zeuzem, Stefan, Colombo, Massimo, Weiland, Ola, Sarrazin, Christoph
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2014
Subjects:	Adult Antiviral Agents - administration & dosage Drug Therapy, Combination eRVR Female Gastroenterology and Hepatology Genotype HCV RNA assay Hepacivirus - genetics Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Humans Interferon-alpha - administration & dosage Male Middle Aged Oligopeptides - administration & dosage Polyethylene Glycols - administration & dosage Real-Time Polymerase Chain Reaction - methods Recombinant Proteins - administration & dosage Response-guided therapy Ribavirin - administration & dosage RNA, Viral - blood RNA, Viral - genetics Serine Proteinase Inhibitors - administration & dosage Telaprevir Time Factors Viral Load - drug effects Viremia - virology ART CAP HPS/CTM eRVR HCV RNA assay Telaprevir Response-guided therapy RGT SVR extended virologic response COBAS TaqMan for use with the HighPure system response-guided treatment Abbott RealTime HCV assay COBAS AmpliPrep/COBAS TaqMan HCV test v2.0 sustained virologic response
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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