Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides

•The endogenous ligands of NKT cells are α-linked monoglycosylceramides.•α-Linked monoglycosylceramides were thought to be absent from mammalian lipidomes.•New tools have been built to study the chemical structure of glycolipids.•Availability of endogenous α-galactosylceramide is regulated by degrad...

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Veröffentlicht in:	Molecular immunology Jg. 68; H. 2; S. 94 - 97
Hauptverfasser:	Kain, Lisa, Costanzo, Anne, Webb, Bill, Holt, Marie, Bendelac, Albert, Savage, Paul B., Teyton, Luc
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.12.2015
Schlagworte:	Animals Anomers Antigen Presentation - genetics Antigen-Presenting Cells - cytology Antigen-Presenting Cells - immunology Antigens, CD1d - immunology Antigens, CD1d - metabolism bioassays Ceramide Ceramides - chemistry Ceramides - classification Ceramides - immunology Ceramides - metabolism chemical analysis Contamination Endogenous ligand enzymes Glucosyltransferases - genetics Glucosyltransferases - immunology Humans Killer Cells, Natural - cytology Killer Cells, Natural - immunology ligands mammals N-Acylsphingosine Galactosyltransferase - genetics N-Acylsphingosine Galactosyltransferase - immunology NKT cells T-lymphocytes Thymic selection Thymocytes - cytology Thymocytes - immunology Thymus Gland Ceramide Anomers NKT cells Thymic selection Endogenous ligand Contamination
ISSN:	0161-5890, 1872-9142, 1872-9142
Online-Zugang:	Volltext
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