Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas

Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the Un...

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Veröffentlicht in:Diagnostics (Basel) Jg. 13; H. 3; S. 361
Hauptverfasser: Cinotti, Elisa, Brunetti, Tullio, Cartocci, Alessandra, Tognetti, Linda, Suppa, Mariano, Malvehy, Josep, Perez-Anker, Javiera, Puig, Susanna, Perrot, Jean Luc, Rubegni, Pietro
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 18.01.2023
MDPI
Schlagworte:
basal cell carcinoma
Cancer
Carcinoma
Dermatology
Diagnosis
Disease
Histopathology
imaging
Medical diagnosis
Melanoma
Methods
optical coherence tomography
Optical tomography
Skin cancer
squamous cell carcinoma
Tomography
tumor
Tumors
Italy
basal cell carcinoma
optical coherence tomography
imaging
tumor
squamous cell carcinoma
ISSN:2075-4418, 2075-4418
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Zusammenfassung:Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (p = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13030361