Therapeutic Drug Monitoring by Dried Blood Spot: Progress to Date and Future Directions

This article discusses dried blood spot (DBS) sampling in therapeutic drug monitoring (TDM). The most important advantages of DBS sampling in TDM are the minimally invasive procedure of a finger prick (home sampling), the small volume (children), and the stability of the analyte. Many assays in DBS...

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Bibliographic Details
Published in:Clinical pharmacokinetics Vol. 53; no. 11; pp. 961 - 973
Main Authors: Wilhelm, Abraham J., den Burger, Jeroen C. G., Swart, Eleonora L.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.11.2014
Adis International
Springer Nature B.V
Subjects:
Biological and medical sciences
Blood Specimen Collection
Dried Blood Spot Testing - methods
Dried Blood Spot Testing - trends
Drug Monitoring - methods
Drug Monitoring - trends
General pharmacology
Hematocrit
Humans
Immunosuppressive Agents - blood
Internal Medicine
Medical sciences
Medicine
Medicine & Public Health
Netherlands
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacotherapy
Plasma - chemistry
Reproducibility of Results
Review
Review Article
Tandem Mass Spectrometry
Netherlands
Paper Spray
Guanfacine
Finger Prick
Therapeutic Drug Monitoring
Proficiency Testing Program
Human
Therapeutic drug monitoring
Biological fluid
Updating
Blood
ISSN:0312-5963, 1179-1926, 1179-1926
Online Access:Get full text
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Description
Summary:This article discusses dried blood spot (DBS) sampling in therapeutic drug monitoring (TDM). The most important advantages of DBS sampling in TDM are the minimally invasive procedure of a finger prick (home sampling), the small volume (children), and the stability of the analyte. Many assays in DBS have been reported in the literature over the previous 5 years. These assays and their analytical techniques are reviewed here. Factors that may influence the accuracy and reproducibility of DBS methods are also discussed. Important issues are the correlation with plasma/serum concentrations and the influence of hematocrit on spot size and recovery. The different substrate materials are considered. DBS sampling can be a valid alternative to conventional venous sampling. However, patient correlation studies are indispensable to prove this. Promising developments are dried plasma spots using membrane and hematocrit correction using the potassium concentration.
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ISSN:0312-5963
1179-1926
1179-1926
DOI:10.1007/s40262-014-0177-7