LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study

Several genes have been implicated in the pathogenesis of Parkinson's disease (PD). The aim of this study was to define the clinical symptoms and age-associated cumulative incidence of the most frequent mutation associated with PD, LRRK2 Gly2019Ser. 238 patients with sporadic PD and 371 unrelat...

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Veröffentlicht in:	Lancet neurology Jg. 7; H. 7; S. 591 - 594
Hauptverfasser:	Hulihan, Mary M, Ishihara-Paul, Lianna, Kachergus, Jennifer, Warren, Liling, Amouri, Rim, Elango, Ramu, Prinjha, Rab K, Upmanyu, Ruchi, Kefi, Mounir, Zouari, Mourad, Sassi, Samia Ben, Yahmed, Samia Ben, El Euch-Fayeche, Ghada, Matthews, Paul M, Middleton, Lefkos T, Gibson, Rachel A, Hentati, Fayçal, Farrer, Matthew J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.07.2008 Elsevier Limited
Schlagworte:	Age Age Factors Case-Control Studies Family medical history Gene Frequency Genetic Predisposition to Disease Genotype Glycine - genetics Haplotypes Humans Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Mutation Mutation - genetics Neurology Parkinson Disease - genetics Parkinson's disease Pathogenesis Patients Penetrance Population Protein-Serine-Threonine Kinases - genetics Residence Characteristics Serine - genetics Tunisia - epidemiology Tunisia - ethnology Tunisia
ISSN:	1474-4422, 1474-4465
Online-Zugang:	Volltext
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