Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity

Glioblastoma is the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the heterogeneous nature of the tumor, which in addition to intrinsic molecular and genetic changes is also influenced by the microenvironmental niche in which the glioma cells reside. The cancer s...

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Bibliographic Details
Published in:	BioMed research international Vol. 2017; no. 2017; pp. 1 - 13
Main Authors:	Ho, Ivy A. W., Shim, Winston
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 01.01.2017 Hindawi John Wiley & Sons, Inc
Subjects:	Animals Brain cancer Cancer therapies Chemotherapy Gene expression Genomes Genotype & phenotype Glioblastoma - immunology Glioblastoma - pathology Glioblastoma - therapy Glioblastoma multiforme Humans Hypotheses Hypoxia Medical prognosis Metabolism Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Neovascularization, Pathologic - therapy Neurosciences Physiological aspects Radiation therapy Review Stem cells Transcription factors Tumor Microenvironment - immunology Tumors Vascular endothelial growth factor
ISSN:	2314-6133, 2314-6141, 2314-6141
Online Access:	Get full text
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