Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy

Appropriate activation of dendritic cells (DC) is essential for successful active vaccination and induction of cell-mediated immunity. The scarcity of precursor cells, as well as long culture methods, have hampered wide-scale application of DC vaccines derived from CD34 + precursors, despite their s...

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Bibliographic Details
Published in:	Cancer Immunology, Immunotherapy Vol. 61; no. 2; pp. 181 - 191
Main Authors:	van de Ven, Rieneke, Reurs, Anneke W., Wijnands, Pepijn G. J. T. B., van Wetering, Sandra, Kruisbeek, Ada M., Hooijberg, Erik, Scheffer, George L., Scheper, Rik J., de Gruijl, Tanja D.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.02.2012 Springer Springer Nature B.V
Subjects:	Anthracyclines - pharmacology Anthraquinones - pharmacology Antigens Antigens, CD34 - metabolism Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cancer Cancer Research Cancer Vaccines Cell Differentiation Cell Line Chemokine CCL19 - metabolism Chemokine CCL21 - metabolism Cytostatic Agents - pharmacology Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Dendritic Cells - transplantation Humans Immunity, Cellular Immunology Immunotherapy Lipopolysaccharide Receptors - metabolism Medical sciences Medicine Medicine & Public Health Myeloid Progenitor Cells - immunology Myeloid Progenitor Cells - metabolism Myeloid Progenitor Cells - pathology Neoplasms - immunology Neoplasms - therapy Oncology Original Original Article Pharmacology. Drug treatments Vaccines Netherlands Dendritic cell Immunotherapy precursors Differentiation Mitoxantrone CD34 Cytostatic drugs Antineoplastic agent Drug Anthraquinone derivatives Cytostatic Stem cell Hematopoietic cell Exposure Malignant tumor Cell differentiation Precursor Cell subpopulation Alkylating agent Treatment Antimetabolic Antigen presenting cell Cancer
ISSN:	0340-7004, 1432-0851, 1432-0851
Online Access:	Get full text
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