CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection

Immunological checkpoints, such as the inhibitory CD200 receptor (CD200R), play a dual role in balancing the immune system during microbial infection. On the one hand these inhibitory signals prevent excessive immune mediated pathology but on the other hand they may impair clearance of the pathogen....

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Bibliographic Details
Published in:	PLoS pathogens Vol. 8; no. 5; p. e1002710
Main Authors:	Karnam, Guruswamy, Rygiel, Tomasz P., Raaben, Matthijs, Grinwis, Guy C. M., Coenjaerts, Frank E., Ressing, Maaike E., Rottier, Peter J. M., de Haan, Cornelis A. M., Meyaard, Linde
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.05.2012 Public Library of Science (PLoS)
Subjects:	Animals Antigens, CD - genetics Antigens, CD - metabolism Biology Coronavirus Infections - immunology Development and progression Female Gender differences Immune system Immunology Influenza A virus - immunology Influenza A virus - pathogenicity Interferon Type I - biosynthesis Medical research Medicine Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Murine hepatitis virus Neutrophil Infiltration Neutrophils - immunology Neutrophils - metabolism Orthomyxoviridae Infections - immunology Pathology Physiological aspects Proteins Rodents Sex Characteristics Signal Transduction Toll-Like Receptor 7 - immunology Toll-Like Receptor 7 - metabolism Viral infections Virulence (Microbiology) Virus diseases United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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