On the utility of pooling biological samples in microarray experiments

Over 15% of the data sets catalogued in the Gene Expression Omnibus Database involve RNA samples that have been pooled before hybridization. Pooling affects data quality and inference, but the exact effects are not yet known because pooling has not been systematically studied in the context of micro...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 102; číslo 12; s. 4252
Hlavní autori:	Kendziorski, C, Irizarry, R A, Chen, K-S, Haag, J D, Gould, M N
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 22.03.2005
Predmet:	Analysis of Variance Animals Female Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Nicotinic Acids - pharmacology Oligonucleotide Array Sequence Analysis - methods Oligonucleotide Array Sequence Analysis - statistics & numerical data Rats Rats, Inbred WF Retinoid X Receptors - agonists RNA - genetics Tetrahydronaphthalenes - pharmacology
ISSN:	0027-8424
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