Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects

Protein homeostasis is an emerging component of schizophrenia (SZ) pathophysiology. Proteomic alterations in SZ are well-documented and changes in transcript expression are frequently not associated with changes in protein expression in SZ brain. The underlying mechanism driving these changes remain...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 25; no. 4; pp. 776 - 790
Main Authors:	Scott, Madeline R, Meador-Woodruff, James H
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2020
Subjects:	Aged Autopsy Brain - metabolism Caspase Cerebral Cortex - metabolism Chymotrypsin Chymotrypsin - analysis Cortex (temporal) Cytosol Degradation Enzymatic activity Female Homeostasis Humans Intracellular Localization Male Mental disorders Middle Aged Pathophysiology Proteasome Endopeptidase Complex - metabolism Proteasomes Protein biosynthesis Protein expression Proteins Proteins - metabolism Proteolysis Proteomics Schizophrenia Schizophrenia - metabolism Superior temporal gyrus Temporal gyrus Temporal Lobe - metabolism Temporal Lobe - pathology Transcription factors Trypsin Trypsin - analysis Ubiquitin Ubiquitin - metabolism
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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