Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient mice

Herpes simplex virus (HSV) type 1 and bovine herpesviruses 1 and 5 (BHV-1 and BHV-5) can use the same cellular receptor for entry, but only HSV is known to cause disease in mice. We hypothesized that components of either the innate or the adaptive immune system, or a combination of both, were respon...

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Veröffentlicht in:	Journal of virology Jg. 78; H. 7; S. 3644
Hauptverfasser:	Abril, Carlos, Engels, Monika, Liman, Anne, Hilbe, Monika, Albini, Sarah, Franchini, Marco, Suter, Mark, Ackermann, Mathias
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2004
Schlagworte:	Animals Axonal Transport Brain - virology Cattle Disease Models, Animal DNA, Viral - analysis DNA, Viral - genetics Herpesviridae Infections - immunology Herpesviridae Infections - virology Herpesvirus 1, Bovine - genetics Herpesvirus 1, Bovine - immunology Herpesvirus 1, Bovine - pathogenicity Herpesvirus 1, Bovine - physiology Herpesvirus 5, Bovine - genetics Herpesvirus 5, Bovine - immunology Herpesvirus 5, Bovine - pathogenicity Herpesvirus 5, Bovine - physiology Interferon-gamma - immunology Mice Neurons - virology Receptors, Interferon - deficiency Th1 Cells - immunology Viremia Virulence Virus Replication
ISSN:	0022-538X
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