Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis

Hypoxia and lymphangiogenesis are closely related processes that play a pivotal role in tumor invasion and metastasis. Intratumoral hypoxia is exacerbated as a result of oxygen consumption by rapidly proliferating tumor cells, insufficient blood supply and poor lymph drainage. Hypoxia induces functi...

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Vydané v:Cancer letters Ročník 346; číslo 1; s. 6 - 16
Hlavný autor: Ji, Rui-Cheng
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Ireland Elsevier Ireland Ltd 28.04.2014
Elsevier Limited
Predmet:
Angiogenesis
Animals
Breast cancer
Cell adhesion & migration
Cell growth
Cell Hypoxia - physiology
Chemokines
Hematology, Oncology and Palliative Medicine
HIF-1α
Humans
Hypoxia
Lymphangiogenesis
Lymphangiogenesis - physiology
Lymphatic endothelial cells
Lymphatic Metastasis - physiopathology
Lymphatic system
Permeability
Proteins
Rodents
Signal transduction
Transcription factors
Tumor metastasis
Tumor Microenvironment - physiology
Vascular endothelial growth factor
VEGF-A/-C/-D
Hypoxia
HIF-1α
Lymphatic endothelial cells
Lymphangiogenesis
VEGF-A/-C/-D
Tumor metastasis
ISSN:0304-3835, 1872-7980, 1872-7980
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Popis
Shrnutí:Hypoxia and lymphangiogenesis are closely related processes that play a pivotal role in tumor invasion and metastasis. Intratumoral hypoxia is exacerbated as a result of oxygen consumption by rapidly proliferating tumor cells, insufficient blood supply and poor lymph drainage. Hypoxia induces functional responses in lymphatic endothelial cells (LECs), including cell proliferation and migration. Multiple factors (e.g., ET-1, AP-1, C/EBP-δ, EGR-1, NF-κB, and MIF) are involved in the events of hypoxia-induced lymphangiogenesis. Among them, HIF-1α is known to be the master regulator of cellular oxygen homeostasis, mediating transcriptional activation of lymphangiogenesis via regulation of signaling cascades like VEGF-A/-C/-D, TGF-β and Prox-1 in experimental and human tumors. Although the underlying molecular mechanisms remain incompletely elucidated, the investigation of lymphangiogenesis in hypoxic conditions may provide insight into potential therapeutic targets for lymphatic metastasis.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0304-3835
1872-7980
1872-7980
DOI:10.1016/j.canlet.2013.12.001