Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis

Hypoxia and lymphangiogenesis are closely related processes that play a pivotal role in tumor invasion and metastasis. Intratumoral hypoxia is exacerbated as a result of oxygen consumption by rapidly proliferating tumor cells, insufficient blood supply and poor lymph drainage. Hypoxia induces functi...

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Bibliographic Details
Published in:	Cancer letters Vol. 346; no. 1; pp. 6 - 16
Main Author:	Ji, Rui-Cheng
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 28.04.2014 Elsevier Limited
Subjects:	Angiogenesis Animals Breast cancer Cell adhesion & migration Cell growth Cell Hypoxia - physiology Chemokines Hematology, Oncology and Palliative Medicine HIF-1α Humans Hypoxia Lymphangiogenesis Lymphangiogenesis - physiology Lymphatic endothelial cells Lymphatic Metastasis - physiopathology Lymphatic system Permeability Proteins Rodents Signal transduction Transcription factors Tumor metastasis Tumor Microenvironment - physiology Vascular endothelial growth factor VEGF-A/-C/-D Hypoxia HIF-1α Lymphatic endothelial cells Lymphangiogenesis VEGF-A/-C/-D Tumor metastasis
ISSN:	0304-3835, 1872-7980, 1872-7980
Online Access:	Get full text
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