Fatty acid oxidation: An emerging facet of metabolic transformation in cancer

Cancer cells undergo metabolic reprogramming such as enhanced aerobic glycolysis, mutations in the tricarboxylic acid cycle enzymes, and upregulation of de novo lipid synthesis and glutaminolysis. These alterations are pivotal to the development and maintenance of the malignant phenotype of cancer c...

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Veröffentlicht in:	Cancer letters Jg. 435; S. 92 - 100
Hauptverfasser:	Ma, Yibao, Temkin, Sarah M., Hawkridge, Adam M., Guo, Chunqing, Wang, Wei, Wang, Xiang-Yang, Fang, Xianjun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Ireland Elsevier B.V 28.10.2018 Elsevier Limited
Schlagworte:	Angina pectoris Apoptosis ATP Biosynthesis Breast cancer Cancer Cell growth Cell proliferation Cell Transformation, Neoplastic - metabolism Dehydrogenases Drug resistance Energy Metabolism Enzymes Fatty acid β-oxidation Fatty acids Fatty Acids - metabolism Genetic transformation Glycolysis Humans Kinases Leukemia Lipid Metabolism Lipolysis Lipolytic phenotype Medical research Medicine Metabolic pathways Metabolism Metastases Metastasis Mitochondria Mitochondria - metabolism NADPH Neoplasms - metabolism Neoplasms - pathology NMR Nuclear magnetic resonance Oxidation Oxidation-Reduction Phenotypes Prostate cancer Transgenic animals Tricarboxylic acid cycle Tumor Microenvironment Tumorigenesis Asia Europe NADPH Fatty acid β-oxidation ATP Lipolytic phenotype Cancer
ISSN:	0304-3835, 1872-7980, 1872-7980
Online-Zugang:	Volltext
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