Bortezomib resistance in multiple myeloma is associated with increased serine synthesis

Background The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the wide-spread occurrence of resistance. Metabolic alterations play an important role in cancer development and aid in the cellular adaptation to phar...

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Bibliographic Details
Published in:	Cancer & metabolism Vol. 5; no. 1; pp. 7 - 12
Main Authors:	Zaal, Esther A., Wu, Wei, Jansen, Gerrit, Zweegman, Sonja, Cloos, Jacqueline, Berkers, Celia R.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.08.2017 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Apoptosis Biomedical and Life Sciences Biomedicine Biosynthesis Bortezomib Breast cancer Cancer Research Cancer therapies Carbon Cell Biology Cell growth Dehydrogenases Drug resistance Drug therapy Experiments Imaging Inhibitor drugs Mass spectrometry Melanoma Metabolic Diseases Metabolism Metabolomics Multiple myeloma Mutation Oncology Patient outcomes Penicillin PHGDH Proteins Radiology Scientific imaging Targeted cancer therapy Testing PHGDH Bortezomib Metabolism Drug resistance Multiple myeloma
ISSN:	2049-3002, 2049-3002
Online Access:	Get full text
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