HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit qualitatively similar changes in miRNA profile in MCF-7 breast cancer cells, a subset of changes are distinct and p95HER2 shifts the miRNA profile towar...

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Veröffentlicht in:	Scientific reports Jg. 9; H. 1; S. 3352
Hauptverfasser:	Gorbatenko, Andrej, Søkilde, Rolf, Sorensen, Ester E., Newie, Inga, Persson, Helena, Morancho, Beatriz, Arribas, Joaquin, Litman, Thomas, Rovira, Carlos, Pedersen, Stine Falsig
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 04.03.2019 Nature Publishing Group
Schlagworte:	13/89 13/95 3' Untranslated regions 38/1 38/77 38/91 631/80/304 692/4028/67/1665 96/109 Basic Medicine Binding sites Breast cancer c-Myb protein Cancer and Oncology Cancer och onkologi Cell adhesion & migration Cell and Molecular Biology Cell migration Cell- och molekylärbiologi Clinical Medicine Clonal deletion ErbB-2 protein Estrogen receptors Estrogens Gene regulation Humanities and Social Sciences Klinisk medicin Matrix metalloproteinase Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Metalloproteinase miRNA multidisciplinary MYB protein Science Science (multidisciplinary) Tissue inhibitor of metalloproteinase 2 Transcription factors
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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