Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation

The activation of the Ras-related GTPase R-Ras, which has been implicated in the regulation of various cellular functions, by G protein-coupled receptors (GPCRs) was studied in HEK-293 cells stably expressing the M3 muscarinic acetylcholine receptor (mAChR), which can couple to several types of hete...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 281; no. 31; p. 21837
Main Authors:	De Jesús, Maider López, Stope, Matthias B, Weernink, Paschal A Oude, Mahlke, Yvonne, Börgermann, Christof, Ananaba, Viktoria N, Rimmbach, Christian, Rosskopf, Dieter, Michel, Martin C, Jakobs, Karl H, Schmidt, Martina
Format:	Journal Article
Language:	English
Published:	United States 04.08.2006
Subjects:	Catalysis Cell Line Cyclic AMP - metabolism GTP Phosphohydrolases - metabolism Guanine Nucleotide Exchange Factors - metabolism Guanosine Diphosphate - metabolism Humans Phospholipase D - metabolism ras Proteins - metabolism Receptor, Muscarinic M3 - metabolism Receptors, G-Protein-Coupled - metabolism Signal Transduction
ISSN:	0021-9258
Online Access:	Get more information
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