Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism
Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions a...
Uložené v:
| Vydané v: | Cancer & metabolism Ročník 4; číslo 1; s. 5 |
|---|---|
| Hlavný autor: | |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
BioMed Central
08.03.2016
BioMed Central Ltd Springer Nature B.V |
| Predmet: | |
| ISSN: | 2049-3002, 2049-3002 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s–1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg’s reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. World politics and world wars heavily affected Warburg’s scientific survival in Berlin. But, after his second postwar recovery, Warburg’s drive for unraveling the energetic processes of life, both in plants and in tumor cells, continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also the identification of the “respiratory ferment” and hydrogen-transferring cofactors and the isolation of glycolytic enzymes. His hypothesis of respiratory damage being the cause of cancer remains to be a provocative scientific issue, along with its implications for cancer treatment and prevention. Warburg is therefore still stimulating our thinking, as documented in a soaring increase in publications citing his name in the context of tumor metabolism. |
|---|---|
| AbstractList | Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s–1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg’s reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. World politics and world wars heavily affected Warburg’s scientific survival in Berlin. But, after his second postwar recovery, Warburg’s drive for unraveling the energetic processes of life, both in plants and in tumor cells, continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also the identification of the “respiratory ferment” and hydrogen-transferring cofactors and the isolation of glycolytic enzymes. His hypothesis of respiratory damage being the cause of cancer remains to be a provocative scientific issue, along with its implications for cancer treatment and prevention. Warburg is therefore still stimulating our thinking, as documented in a soaring increase in publications citing his name in the context of tumor metabolism. Virtually everyone working in cancer research is familiar with the "Warburg effect", i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s-1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg's reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. World politics and world wars heavily affected Warburg's scientific survival in Berlin. But, after his second postwar recovery, Warburg's drive for unraveling the energetic processes of life, both in plants and in tumor cells, continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also the identification of the "respiratory ferment" and hydrogen-transferring cofactors and the isolation of glycolytic enzymes. His hypothesis of respiratory damage being the cause of cancer remains to be a provocative scientific issue, along with its implications for cancer treatment and prevention. Warburg is therefore still stimulating our thinking, as documented in a soaring increase in publications citing his name in the context of tumor metabolism. Keywords: Biography, Warburg effect, Glycolysis, Respiration, NAD(P)H, Tumor cells, Spectroscopy, Manometer, Hypothesis, Nobel prize Virtually everyone working in cancer research is familiar with the "Warburg effect", i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s-1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg's reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. World politics and world wars heavily affected Warburg's scientific survival in Berlin. But, after his second postwar recovery, Warburg's drive for unraveling the energetic processes of life, both in plants and in tumor cells, continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also the identification of the "respiratory ferment" and hydrogen-transferring cofactors and the isolation of glycolytic enzymes. His hypothesis of respiratory damage being the cause of cancer remains to be a provocative scientific issue, along with its implications for cancer treatment and prevention. Warburg is therefore still stimulating our thinking, as documented in a soaring increase in publications citing his name in the context of tumor metabolism.Virtually everyone working in cancer research is familiar with the "Warburg effect", i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences and the historical landmarks in his life. His creative and innovative thinking and his experimental virtuosity set the framework for his scientific achievements, which were pioneering not only for cancer research. Here, I shall allude to the prestigious family background in imperial Germany; his relationships to Einstein, Meyerhof, Krebs, and other Nobel and notable scientists; his innovative technical developments and their applications in the advancement of biomedical sciences, including the manometer, tissue slicing, and cell cultivation. The latter were experimental prerequisites for the first metabolic measurements with tumor cells in the 1920s. In the 1930s-1940s, he improved spectrophotometry for chemical analysis and developed the optical tests for measuring activities of glycolytic enzymes. Warburg's reputation brought him invitations to the USA and contacts with the Rockefeller Foundation; he received the Nobel Prize in 1931. World politics and world wars heavily affected Warburg's scientific survival in Berlin. But, after his second postwar recovery, Warburg's drive for unraveling the energetic processes of life, both in plants and in tumor cells, continued until his death in 1970. The legacy of Otto Warburg is not only the Warburg effect, but also the identification of the "respiratory ferment" and hydrogen-transferring cofactors and the isolation of glycolytic enzymes. His hypothesis of respiratory damage being the cause of cancer remains to be a provocative scientific issue, along with its implications for cancer treatment and prevention. Warburg is therefore still stimulating our thinking, as documented in a soaring increase in publications citing his name in the context of tumor metabolism. |
| ArticleNumber | 5 |
| Audience | Academic |
| Author | Otto, Angela M. |
| Author_xml | – sequence: 1 givenname: Angela M. surname: Otto fullname: Otto, Angela M. email: otto@tum.de organization: Institute of Medical Engineering (IMETUM), Technische Universitaet Muenchen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26962452$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1qFTEYhgep2Fp7AW4kIEhdTM3fJDMboRR_CoVuFFcSkkxyJnUmOSYZwZ0X4RV6JWY4PfWcoiaE_D3vm-TL97g68MGbqnqK4BlCLXuVKEQc1hCx0mhTdw-qIwxpVxMI8cHO-LA6SekGltI2pGPkUXWIWccwbfBR9fmTjGqOK2CsNTqfppe_fvyUQLmwinI9OC1HkL6YrAcQLLjOOYCtQvoeDC4BN62lzgkED_I8hQgmk6UKo0vTk-qhlWMyJ7f9cfXx7ZsPF-_rq-t3lxfnV7VuGM01V1K1kijWNlYqpBqtVN_0neUMkwZBzhDvFVeMtaVJBkmZGyoRVhj2lpHj6vXGdz2ryfTa-BzlKNbRTTJ-F0E6sb_j3SBW4ZugvKW464rB6a1BDF9nk7KYXNJmHKU3YU4CcY5bwtt2QZ_fQ2_CHH15XqG6piOka8kfaiVHI5y3oZyrF1NxTmnDyGJVqLO_UKX2ZnK6_Ld1ZX1P8GJHMBg55iGFcc4u-LQPPtuNyF0otj9fAL4BdAwpRWOFdlkuPuUKbhQIiiXNxCbNREkzsaSZWAKA7im35v_T4I0mFdavTNwJ2j9FvwGh-OL5 |
| CitedBy_id | crossref_primary_10_1016_j_bbcan_2021_188568 crossref_primary_10_3390_cells10061356 crossref_primary_10_1002_agm2_12170 crossref_primary_10_5812_jjcmb_136216 crossref_primary_10_1093_biolre_ioaa217 crossref_primary_10_3389_fendo_2019_00570 crossref_primary_10_3389_fgene_2020_589663 crossref_primary_10_1016_j_prnil_2017_03_004 crossref_primary_10_3389_fcell_2019_00311 crossref_primary_10_1007_s12253_018_0517_2 crossref_primary_10_1021_acsbiomaterials_9b01703 crossref_primary_10_1177_1010428317695968 crossref_primary_10_1002_cbic_202500447 crossref_primary_10_1155_2021_6687291 crossref_primary_10_1016_j_bcp_2021_114809 crossref_primary_10_3390_cancers12051119 crossref_primary_10_1016_j_neurobiolaging_2023_07_002 crossref_primary_10_1097_COC_0000000000001215 crossref_primary_10_1016_j_semcancer_2022_07_003 crossref_primary_10_1242_dev_189340 crossref_primary_10_3892_ijo_2019_4912 crossref_primary_10_1042_EBC20180002 crossref_primary_10_1002_biof_1624 crossref_primary_10_1186_s13045_017_0392_4 crossref_primary_10_1016_j_biopha_2023_116021 crossref_primary_10_1016_j_cell_2024_06_026 crossref_primary_10_1088_2057_1739_aa5cd9 crossref_primary_10_1002_cnr2_1131 crossref_primary_10_1002_wnan_1842 crossref_primary_10_1096_fj_202100040R crossref_primary_10_1016_j_bbcan_2024_189089 crossref_primary_10_3390_antiox9050425 crossref_primary_10_34172_apb_2022_057 crossref_primary_10_1186_s13578_019_0317_8 crossref_primary_10_1007_s11883_025_01321_y crossref_primary_10_3390_cells8101113 crossref_primary_10_1016_j_arr_2024_102551 crossref_primary_10_3390_cells9081900 crossref_primary_10_2147_OTT_S397593 crossref_primary_10_1007_s13546_016_1200_9 crossref_primary_10_3390_ijms221910612 crossref_primary_10_1113_JP278930 crossref_primary_10_1128_spectrum_04293_22 crossref_primary_10_1051_fopen_2021002 crossref_primary_10_3390_cancers16223786 crossref_primary_10_3389_fgene_2022_849040 crossref_primary_10_1002_adtp_202000267 crossref_primary_10_1016_j_jid_2016_04_001 crossref_primary_10_1016_j_semcancer_2022_01_010 crossref_primary_10_1007_s11010_025_05328_6 crossref_primary_10_1007_s11306_018_1398_9 crossref_primary_10_1038_s41598_024_72221_5 crossref_primary_10_1007_s12268_020_1470_7 crossref_primary_10_1002_ejoc_201901224 crossref_primary_10_1016_j_bbcan_2017_05_003 crossref_primary_10_1038_srep41712 crossref_primary_10_1016_j_semcancer_2017_02_003 crossref_primary_10_1038_s41416_020_0778_x crossref_primary_10_1155_2021_5590037 crossref_primary_10_1016_j_phrs_2025_107840 crossref_primary_10_3390_ijms20061385 crossref_primary_10_1016_j_prp_2024_155679 crossref_primary_10_3892_ijmm_2022_5160 crossref_primary_10_1016_j_tranon_2020_100842 crossref_primary_10_1002_cam4_1410 crossref_primary_10_3389_fcell_2021_626316 crossref_primary_10_1210_jc_2017_01991 crossref_primary_10_1111_1440_1681_13874 crossref_primary_10_1016_j_biopha_2022_113801 crossref_primary_10_3390_ijms20163973 crossref_primary_10_1002_jso_25114 crossref_primary_10_1080_14737140_2022_2070153 crossref_primary_10_3390_ijms17071029 crossref_primary_10_4274_atfm_galenos_2021_97659 crossref_primary_10_3892_ol_2022_13593 crossref_primary_10_1016_j_cclet_2021_06_032 crossref_primary_10_1134_S0006297923140018 crossref_primary_10_3390_cancers16132290 crossref_primary_10_1093_procel_pwaf045 crossref_primary_10_3390_cancers16213606 crossref_primary_10_3389_fnins_2020_00920 crossref_primary_10_1089_ars_2022_0046 crossref_primary_10_1007_s00360_024_01549_1 crossref_primary_10_3390_nu13103562 crossref_primary_10_1007_s00109_016_1475_3 crossref_primary_10_1186_s12885_016_2878_9 crossref_primary_10_3389_fnut_2021_634845 crossref_primary_10_1007_s00210_023_02480_y crossref_primary_10_3390_nu12123869 crossref_primary_10_1007_s12011_023_03706_z crossref_primary_10_1016_j_gene_2019_06_025 crossref_primary_10_1016_j_smim_2016_10_009 crossref_primary_10_1038_s41420_018_0122_x crossref_primary_10_3390_cancers16162823 crossref_primary_10_3390_ijms242317060 crossref_primary_10_1089_ten_tec_2024_0368 crossref_primary_10_1016_j_isci_2024_111157 crossref_primary_10_1080_00498254_2023_2180454 crossref_primary_10_3389_fceld_2025_1470093 crossref_primary_10_1016_j_jtemb_2025_127750 crossref_primary_10_1007_s00421_017_3795_6 crossref_primary_10_3390_metabo13020213 crossref_primary_10_3390_ijms232315025 crossref_primary_10_1016_j_jare_2025_08_023 crossref_primary_10_1080_08880018_2023_2295454 |
| Cites_doi | 10.1084/jem.99.2.167 10.2967/jnumed.107.047258 10.7326/0003-4819-116-9-765 10.1515/znb-1970-0332 10.1126/science.124.3215.269 10.1038/nrc3038 10.1126/science.124.3215.270 10.1126/science.124.3215.267 10.1101/SQB.1939.007.01.034 10.1515/znb-1958-0201 10.1016/j.yexmp.2010.08.006 10.1111/j.1469-185X.1962.tb01607.x 10.1126/science.123.3191.309 10.18632/oncoscience.109 10.12703/P7-41 10.1007/BF01504870 10.1007/BF01712130 10.1007/s13148-011-0030-x 10.1085/jgp.8.6.519 10.1007/BF01634476 |
| ContentType | Journal Article |
| Copyright | Otto. 2016 COPYRIGHT 2016 BioMed Central Ltd. Copyright BioMed Central 2016 |
| Copyright_xml | – notice: Otto. 2016 – notice: COPYRIGHT 2016 BioMed Central Ltd. – notice: Copyright BioMed Central 2016 |
| DBID | C6C AAYXX CITATION NPM 3V. 7X7 7XB 88C 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M0T PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| DOI | 10.1186/s40170-016-0145-9 |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Healthcare Administration Database (Alumni) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Local Electronic Collection Information ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Healthcare Administration Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest One Academic Eastern Edition ProQuest Health Management ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2049-3002 |
| ExternalDocumentID | PMC4784299 4086987191 A445638893 26962452 10_1186_s40170_016_0145_9 |
| Genre | Journal Article Review |
| GroupedDBID | 0R~ 53G 5VS 7X7 8FI 8FJ AAFWJ AAJSJ AASML ABUWG ACGFS ADBBV ADRAZ ADUKV AFKRA AFPKN AHBYD AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AOIJS AQUVI ASPBG BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EJD EMOBN FYUFA GROUPED_DOAJ H13 HMCUK HYE IAO IHR IHW INH INR ITC KQ8 M0T M48 M~E OK1 PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PUEGO RBZ ROL RPM RSV SOJ UKHRP AAYXX AFFHD CITATION ALIPV NPM 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c564t-7bab8a3b685fab1b5cbbd5d9f76235107617db7b668b66a60317de4a12b20df63 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 127 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000386838200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2049-3002 |
| IngestDate | Tue Nov 04 01:29:34 EST 2025 Sun Nov 09 11:35:08 EST 2025 Sat Oct 11 13:41:25 EDT 2025 Tue Nov 11 10:57:47 EST 2025 Tue Nov 04 18:18:46 EST 2025 Thu May 22 21:24:05 EDT 2025 Thu Apr 03 06:59:17 EDT 2025 Sat Nov 29 04:00:00 EST 2025 Tue Nov 18 21:41:08 EST 2025 Sat Sep 06 07:25:42 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Spectroscopy Nobel prize Tumor cells Biography Glycolysis NAD(P)H Manometer Respiration Hypothesis Warburg effect |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c564t-7bab8a3b685fab1b5cbbd5d9f76235107617db7b668b66a60317de4a12b20df63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.proquest.com/docview/1795933983?pq-origsite=%requestingapplication% |
| PMID | 26962452 |
| PQID | 1795933983 |
| PQPubID | 2040155 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4784299 proquest_miscellaneous_1772837889 proquest_journals_1795933983 gale_infotracmisc_A445638893 gale_infotracacademiconefile_A445638893 gale_healthsolutions_A445638893 pubmed_primary_26962452 crossref_citationtrail_10_1186_s40170_016_0145_9 crossref_primary_10_1186_s40170_016_0145_9 springer_journals_10_1186_s40170_016_0145_9 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-03-08 |
| PublicationDateYYYYMMDD | 2016-03-08 |
| PublicationDate_xml | – month: 03 year: 2016 text: 2016-03-08 day: 08 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Cancer & metabolism |
| PublicationTitleAbbrev | Cancer Metab |
| PublicationTitleAlternate | Cancer Metab |
| PublicationYear | 2016 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V |
| References | P Werner (145_CR4) 1988 S Minami (145_CR6) 1923; 142 S Weinhouse (145_CR23) 1956; 124 O Warburg (145_CR10) 1924; 152 O Warburg (145_CR8) 1927; 15 CF Cori (145_CR13) 1925; 65 D Burk (145_CR15) 1939; 7 O Warburg (145_CR5) 1923; 2 PD Stolley (145_CR16) 1992; 116 R Dulbecco (145_CR20) 1954; 99 JS Turner (145_CR1) 1962; 37 RJ Gillies (145_CR26) 2008; 49 O Warburg (145_CR9) 1956; 123 P Bhat (145_CR28) 2011; 2 E Racker (145_CR2) 1972; 60 WH Koppenol (145_CR29) 2011; 11 O Warburg (145_CR25) 1970; b 25 O Warburg (145_CR19) 1958; 13 KO Alfarouk (145_CR30) 2014; 1 D Burk (145_CR7) 1941; 2 D Burk (145_CR21) 1956; 124 O Warburg (145_CR14) 1930; 228 O Warburg (145_CR22) 1956; 124 H Krebs (145_CR3) 1979 145_CR17 O Warburg (145_CR12) 1927; 8 E Hofmann (145_CR18) 1985; 3/N 145_CR24 A Goldfeder (145_CR11) 1929; 29 D Senyilmaz (145_CR31) 2015; 7 LMR Ferreira (145_CR27) 2010; 89 25621294 - Oncoscience. 2014 Dec 18;1(12):777-802 13298683 - Science. 1956 Feb 24;123(3191):309-14 4332766 - Am Sci. 1972 Jan-Feb;60(1):56-63 13351638 - Science. 1956 Aug 10;124(3215):267-9 13923215 - Biol Rev Camb Philos Soc. 1962 Feb;37:130-70 4392802 - Z Naturforsch B. 1970 Mar;25(3):332-3 18523064 - J Nucl Med. 2008 Jun;49 Suppl 2:24S-42S 22704333 - Clin Epigenetics. 2011 Aug;2(2):113-22 13130792 - J Exp Med. 1954 Feb;99(2):167-82 13351639 - Science. 1956 Aug 10;124(3215):269-70 20804748 - Exp Mol Pathol. 2010 Dec;89(3):372-80 19872213 - J Gen Physiol. 1927 Mar 7;8(6):519-30 13351640 - Science. 1956 Aug 10;124(3215):270-2 26097714 - F1000Prime Rep. 2015 Apr 02;7:41 21508971 - Nat Rev Cancer. 2011 May;11(5):325-37 1558350 - Ann Intern Med. 1992 May 1;116(9):765-9 |
| References_xml | – volume: 99 start-page: 167 issue: 2 year: 1954 ident: 145_CR20 publication-title: J Exp Med doi: 10.1084/jem.99.2.167 – volume: 49 start-page: 24S issue: Suppl 2 year: 2008 ident: 145_CR26 publication-title: J Nucl Med doi: 10.2967/jnumed.107.047258 – volume-title: Otto Warburg - Von der Zellphysiologie zur Krebsforschung year: 1988 ident: 145_CR4 – volume: 116 start-page: 765 issue: 9 year: 1992 ident: 145_CR16 publication-title: Ann Intern Med doi: 10.7326/0003-4819-116-9-765 – volume: b 25 start-page: 332 issue: 3 year: 1970 ident: 145_CR25 publication-title: Zeitschr Naturforsch B doi: 10.1515/znb-1970-0332 – volume: 124 start-page: 269 issue: 3215 year: 1956 ident: 145_CR22 publication-title: Science doi: 10.1126/science.124.3215.269 – volume: 60 start-page: 56 issue: 1 year: 1972 ident: 145_CR2 publication-title: Am Sci – volume: 11 start-page: 325 issue: 5 year: 2011 ident: 145_CR29 publication-title: Nat Rev Cancer doi: 10.1038/nrc3038 – volume: 124 start-page: 270 issue: 3215 year: 1956 ident: 145_CR21 publication-title: Science doi: 10.1126/science.124.3215.270 – volume: 124 start-page: 267 issue: 3215 year: 1956 ident: 145_CR23 publication-title: Science doi: 10.1126/science.124.3215.267 – volume: 152 start-page: 309 year: 1924 ident: 145_CR10 publication-title: Biochem Zeitschr – volume: 7 start-page: 420 year: 1939 ident: 145_CR15 publication-title: Cold Spring Harb Symp Quant Biol doi: 10.1101/SQB.1939.007.01.034 – ident: 145_CR17 – volume: 13 start-page: 61 issue: 2 year: 1958 ident: 145_CR19 publication-title: Zeitschr Naturforsch B doi: 10.1515/znb-1958-0201 – volume: 89 start-page: 372 issue: 3 year: 2010 ident: 145_CR27 publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2010.08.006 – volume: 37 start-page: 130 issue: 1 year: 1962 ident: 145_CR1 publication-title: Biol Rev Camb Philos Soc doi: 10.1111/j.1469-185X.1962.tb01607.x – volume: 2 start-page: 201 issue: 3 year: 1941 ident: 145_CR7 publication-title: J Natl Canc Inst – volume: 123 start-page: 309 issue: 3191 year: 1956 ident: 145_CR9 publication-title: Science doi: 10.1126/science.123.3191.309 – volume: 1 start-page: 777 issue: 12 year: 2014 ident: 145_CR30 publication-title: Oncoscience doi: 10.18632/oncoscience.109 – volume: 7 start-page: 41 year: 2015 ident: 145_CR31 publication-title: F1000Prime Rep doi: 10.12703/P7-41 – volume-title: Otto Warburg Zellphysiologe - Biochemiker - Mediziner 1983-1970. Grosse Naturforscher year: 1979 ident: 145_CR3 – volume: 15 start-page: 1 issue: 1 year: 1927 ident: 145_CR8 publication-title: Naturwissenschaften doi: 10.1007/BF01504870 – volume: 228 start-page: 257 issue: 1/3 year: 1930 ident: 145_CR14 publication-title: Biochem Zeitschr – volume: 65 start-page: 397 issue: 2 year: 1925 ident: 145_CR13 publication-title: J Biol Biochem – volume: 2 start-page: 776 issue: 17 year: 1923 ident: 145_CR5 publication-title: Klin Wochenschr doi: 10.1007/BF01712130 – volume: 142 start-page: 334 year: 1923 ident: 145_CR6 publication-title: Biochem Zeitschr – ident: 145_CR24 – volume: 2 start-page: 113 issue: 2 year: 2011 ident: 145_CR28 publication-title: Clin Epigenetics doi: 10.1007/s13148-011-0030-x – volume: 8 start-page: 519 issue: 6 year: 1927 ident: 145_CR12 publication-title: J Gen Physiol doi: 10.1085/jgp.8.6.519 – volume: 29 start-page: 134 issue: 1-2 year: 1929 ident: 145_CR11 publication-title: Zeitschr Krebsforschg doi: 10.1007/BF01634476 – volume: 3/N start-page: 25 year: 1985 ident: 145_CR18 publication-title: Berichte der Akademie der Wissenschaften – reference: 13351638 - Science. 1956 Aug 10;124(3215):267-9 – reference: 19872213 - J Gen Physiol. 1927 Mar 7;8(6):519-30 – reference: 4392802 - Z Naturforsch B. 1970 Mar;25(3):332-3 – reference: 13351640 - Science. 1956 Aug 10;124(3215):270-2 – reference: 1558350 - Ann Intern Med. 1992 May 1;116(9):765-9 – reference: 26097714 - F1000Prime Rep. 2015 Apr 02;7:41 – reference: 20804748 - Exp Mol Pathol. 2010 Dec;89(3):372-80 – reference: 4332766 - Am Sci. 1972 Jan-Feb;60(1):56-63 – reference: 13130792 - J Exp Med. 1954 Feb;99(2):167-82 – reference: 25621294 - Oncoscience. 2014 Dec 18;1(12):777-802 – reference: 18523064 - J Nucl Med. 2008 Jun;49 Suppl 2:24S-42S – reference: 13923215 - Biol Rev Camb Philos Soc. 1962 Feb;37:130-70 – reference: 13351639 - Science. 1956 Aug 10;124(3215):269-70 – reference: 13298683 - Science. 1956 Feb 24;123(3191):309-14 – reference: 22704333 - Clin Epigenetics. 2011 Aug;2(2):113-22 – reference: 21508971 - Nat Rev Cancer. 2011 May;11(5):325-37 |
| RelatedPersons | Warburg, Otto |
| RelatedPersons_xml | – fullname: Warburg, Otto |
| SSID | ssj0000853963 |
| Score | 2.3609712 |
| SecondaryResourceType | review_article |
| Snippet | Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells.... Virtually everyone working in cancer research is familiar with the "Warburg effect", i.e., anaerobic glycolysis in the presence of oxygen in tumor cells.... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 5 |
| SubjectTerms | Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cancer Research Cell Biology Cell metabolism Forecasts and trends Health aspects Imaging Metabolic Diseases Metabolomics Oncology Oncology, Experimental Radiology Review Warburg, Otto |
| SummonAdditionalLinks | – databaseName: Springer Standard Collection dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3JbtUw0IKCEBfKTtoCRkICiiKyOLZzrBAVByiIpfSCIk_i0Ii-BL3k9cxH8IV8CTPOouYJkOAQKZLHyWQWe5zZGHuoVQEyscI3ANoXeVjinbW-CfFEpCwazK588eErdXCgj47St0MedztGu48uSbdSO7XW8lkrAtckJaQTsEj89Dy7gLudJm189_5w-rGCNkSMUjV4MH87c7YHra_EZ7ai9TDJNV-p24L2N_8L-avsymBx8r1eRK6xc7a-zi69HnzqN9jnT4Yo-4X3oR2P2yc_v_8wHKq-mDUxkbdfibu8Kfmbrmv4OMPUBT-uWt6nWra8qXm3WjRLvrAdCtdJ1S5uso_7Lz48f-kPTRf8PJGi8xUY0CYGqZPSQAhJDlAkRVriqhmjAis0eQpQIKXGy1CTalVYYcIIoqAoZXyLbdRNbe8wLlMR0O-SNMhjQcAANpXK4uMTKAA8FoxsyPKhIjk1xjjJ3MlEy6wnW0ZRaES2LPXY7jTlW1-O42_A94m3WZ9ROqlytifQaow1Wmoee-QgSJnxzbkZchIQfyqLNYPcmUGiEubz4VF-smERaLOQ-rjHcapx-ME0TDMpsK22zYpgVORq-iO2t3txmz4skqkkx7jH1EwQJwAqDT4fqatjVyJcKE2GhseejuJ4Bq0_0Wvrn6C32eXIyXPsB3qHbXTLlb3LLuanXdUu7zmd_AX-FTLX priority: 102 providerName: Springer Nature |
| Title | Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism |
| URI | https://link.springer.com/article/10.1186/s40170-016-0145-9 https://www.ncbi.nlm.nih.gov/pubmed/26962452 https://www.proquest.com/docview/1795933983 https://www.proquest.com/docview/1772837889 https://pubmed.ncbi.nlm.nih.gov/PMC4784299 |
| Volume | 4 |
| WOSCitedRecordID | wos000386838200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: Open Access: BioMedCentral Open Access Titles customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: RBZ dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: DOA dateStart: 20130101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: M~E dateStart: 20130101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: 7X7 dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Healthcare Administration Database customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: M0T dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: BENPR dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: PIMPY dateStart: 20150101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: Springer Standard Collection customDbUrl: eissn: 2049-3002 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000853963 issn: 2049-3002 databaseCode: RSV dateStart: 20131201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1rb9Mw8MQ6hPjC-xEYxUhIvBQtD8d2PqGBNoFESzXGVsSHyE5cVrEmo0n5_fgcNyyV2Bc-NGrqc2rnHj7fne8AngteKJZo6kulhE_zcGa-ae3L0OyIuDYKs01ffPyJj8diOk0nzuBWu7DKtUy0grqocrSR74ZYFDuOUxG_Pf_lY9Uo9K66EhpbsI2ZyugAtt_tjyeHnZXFKBSxITHnzgwF261pYGuthLiRpomf9hakTbF8YV3ajJnccJza9ejg5v_O5BbccJoo2WtJ5zZc0eUduDZyvva78P1E4hv_QdqQj5f1K18SNW9TXCNqSf0TcU6qGfncNBVZw8uyIKfzmrQHMGtSlaRZLaolWejGkNzZvF7cg68H-0fvP_iuFIOfJ4w2PldSCRkrJpKZVKFKcqWKpEhnRpbGhq25UYQKxRVjwnwklq7mhaYyjFQUFDMW34dBWZX6IRCW0gCNKGmQxxSBldIp49o8PlGFUh4Ea3xkuctTjuUyzjK7XxEsa1GYYWwaojBLPXjddTlvk3RcBvwUkZy150w7Bs_2qNElY2H0Nw9eWAhkcfPPuXQnFcz4MVlWD3KnB2lYM-83rykgc6Khzv6i34NnXTP2xHC3UlcrhOGRzfRvRvugpbtuYhFLGbrLPeA9iuwAMGF4v6Wcn9rE4ZQLVD88eLOm3QvD-tf7enT5JB7D9cgyU-wHYgcGzXKln8DV_Hczr5dD2OJTbq9i6HhzaM0e5joKjsxvk4-jyTdzd_jl-A8uQkOe |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgoAL70egUCOBgKKoeTrOAaEKqFp1d-GwhUocUjtxaEQ3KZssiD_Fb2QmL5qV6K0HDpEieZz48c14xh7PADwVQaK4rz1TKiVML7ZTfNPalDZaRIFGhbkOX_xpFEwm4uAg_LgCv7u7MORW2cnEWlAnRUx75Js2JcV23VC4b06-m5Q1ik5XuxQaDSz29K-faLKVr3ff4fw-c5zt99O3O2abVcCMfe5VZqCkEtJVXPipVLbyY6USPwlTFAsuIhTtemx_oDgX-EjKwhwk2pO2oxwrSbmL370AFymuHrkQjq1pv6eD6ouLgG4PT23BN0vPqjO72GS2e74ZDpa_5UXg1Cq47KG5dExbr37b1_-3cbsB11o9m201jHETVnR-Cy6PW0-C2_DlsyQ8fWWNQ8uL8qUpmcqaAN4EXFZ-I0SzImUfqqpgHb3ME3aUlay5XlqyImfVYlbM2UxXyFDHWTm7A_vn0rW7sJoXub4PjIeeRVtEoRW7HhErpUMeaPy8rxKlDLC6-Y_iNgo7JQM5jmprTPCogUxEnncEmSg0YKOvctKEIDmLeJ1AFTW3aHvxFW15qCm7ArVTA57XFCTA8M-xbO9hYPspFNiAcm1AiYInHhZ3iItawVdGf-FmwJO-mGqSM1-uiwXRBE6dxwBbe6_Bed8xh4ecnAEMCAYc0BNQOPRhSZ4d1WHRvUCQcmXAq45XTjXrX-P14OxOrMOVnel4FI12J3sP4apTM7JrWmINVqv5Qj-CS_GPKivnj2tJwODwvFnoD8tXmV8 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9UwEA66yuKL90t1dSMI3ijbS5qkj4t6UFyPC-q6L0vItKlb3NMupz0--yP8hf4SM01btgcVxIdCIZM2l5lkJjP5hpBHUuTAE8N8DSB9loWFfTPG16G1iISxCnMHX3ywJ-ZzeXiY7vd5Tpsh2n1wSbo7DYjSVLU7p3nhRFzynYYFXcKUEK1hlvjpeXKBYc4gNNc_HIyHLFafiC2H9d7M39ac7Efrq_KZbWk9ZHLNb9ptR7Mr_92Rq-Ryr4nSXcc618g5U10nm-96X_sNcvRZ44h_oS7k40nz9Of3H5pC6UCucXJp8xVnndYFfd-2NR1q6Cqnx2VD3RXMhtYVbVeLekkXprVMd1I2i5vk0-zVxxev_T4Zg58lnLW-AA1Sx8BlUmgIIckA8iRPC7uaxlawhVWFchDAubSPxuTVIjdMhxFEQV7w-BbZqOrK3CGUpyzAY5Q0yGKGxAAm5cLYzyeQA3gkGKZEZT1SOSbMOFGdxSK5csOmMDoNh02lHnk2Vjl1MB1_I97GeVbupuko4mqXWW0yllaD88jjjgKF3P450_1dBdt-hMuaUG5NKK1wZtPigZdUvzg0KsT87nGcSlv8cCzGmhjwVpl6hTQi6rD-bWtvO9YbOxbxlKPD3CNiwpQjAUKGT0uq8riDDmdCogLikecDa55p1p_G6-4_UW-Tzf2XM7X3Zv72HrkUdawd-4HcIhvtcmXuk4vZt7Zslg86Uf0Fdnw-nw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Warburg+effect%28s%29-a+biographical+sketch+of+Otto+Warburg+and+his+impacts+on+tumor+metabolism&rft.jtitle=Cancer+%26+metabolism&rft.au=Otto%2C+Angela+M&rft.date=2016-03-08&rft.pub=Springer+Nature+B.V&rft.eissn=2049-3002&rft.volume=4&rft_id=info:doi/10.1186%2Fs40170-016-0145-9&rft.externalDocID=4086987191 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2049-3002&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2049-3002&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2049-3002&client=summon |