Sample normalization methods in quantitative metabolomics

•Sample-to-sample amount variation could be larger than analytical variation.•Sample normalization is a critical step in quantitative metabolomics.•Sample normalization should be incorporated into a metabolomic profiling workflow.•There is no unified method but a number of methods have been reported...

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Bibliographic Details
Published in:	Journal of Chromatography A Vol. 1430; pp. 80 - 95
Main Authors:	Wu, Yiman, Li, Liang
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 22.01.2016
Subjects:	Analytic Sample Preparation Methods - methods Analytic Sample Preparation Methods - standards chromatography Chromatography, Liquid - methods Collection Data processing Feature extraction Humans Liquid chromatography Mass spectrometry Mass Spectrometry - methods Mathematical analysis Metabolite quantification Metabolites Metabolomics Metabolomics - methods Metabolomics - standards Platforms Quantitative metabolomic profiling Sample normalization Specimen Handling - methods Specimen Handling - standards Workflow Metabolomics Quantitative metabolomic profiling Liquid chromatography Mass spectrometry Sample normalization Metabolite quantification
ISSN:	0021-9673, 1873-3778, 1873-3778
Online Access:	Get full text
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