Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent del...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 43; H. 4; S. 113988
Hauptverfasser:	Kuzmin, Elena, Baker, Toby M., Lesluyes, Tom, Monlong, Jean, Abe, Kento T., Coelho, Paula P., Schwartz, Michael, Del Corpo, Joseph, Zou, Dongmei, Morin, Genevieve, Pacis, Alain, Yang, Yang, Martinez, Constanza, Barber, Jarrett, Kuasne, Hellen, Li, Rui, Bourgey, Mathieu, Fortier, Anne-Marie, Davison, Peter G., Omeroglu, Atilla, Guiot, Marie-Christine, Morris, Quaid, Kleinman, Claudia L., Huang, Sidong, Gingras, Anne-Claude, Ragoussis, Jiannis, Bourque, Guillaume, Van Loo, Peter, Park, Morag
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 23.04.2024 Cell Press Elsevier
Schlagworte:	aneuploidy Animals basal breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer cancer evolution Cell Line, Tumor Cell Proliferation - genetics chromosomal arm copy number aberrations chromosome 4p Chromosome Aberrations Chromosomes, Human, Pair 4 - genetics CP: Cancer CP: Genomics Female GCK-III Gene Regulatory Networks Humans Life Sciences Mice PDCD10 Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology triple-negative breast cancer triple-negative breast cancer chromosomal arm copy number aberrations chromosome 4p PDCD10 CP: Cancer aneuploidy basal breast cancer CP: Genomics cancer evolution GCK-III
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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