Structural basis for selectivity in a highly reducing type II polyketide synthase

In type II polyketide synthases (PKSs), the ketosynthase–chain length factor (KS–CLF) complex catalyzes polyketide chain elongation with the acyl carrier protein (ACP). Highly reducing type II PKSs, represented by IgaPKS, produce polyene structures instead of the well-known aromatic skeletons. Here,...

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Bibliographic Details
Published in:	Nature chemical biology Vol. 16; no. 7; pp. 776 - 782
Main Authors:	Du, Danyao, Katsuyama, Yohei, Horiuchi, Masanobu, Fushinobu, Shinya, Chen, Aochiu, Davis, Tony D., Burkart, Michael D., Ohnishi, Yasuo
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.07.2020 Nature Publishing Group
Subjects:	631/535/1266 631/92/60 631/92/607 Acyl carrier protein Acyl Carrier Protein - chemistry Acyl Carrier Protein - genetics Acyl Carrier Protein - metabolism Antifungal agents Biocatalysis Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis Catalytic Domain Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cloning, Molecular Condensates Condensation Crosslinking Crystal structure Crystallography, X-Ray E coli Elongation Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fatty Acid Synthases - chemistry Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty acids Fatty-acid synthase Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism Models, Molecular Molecular interactions Molecular structure Mutagenesis Mutagenesis, Site-Directed Polyketide synthase Polyketide Synthases - chemistry Polyketide Synthases - genetics Polyketide Synthases - metabolism Polyketides - chemistry Polyketides - metabolism Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Selectivity Site-directed mutagenesis Streptomyces - enzymology Streptomyces - genetics Substrate Specificity Substrates
ISSN:	1552-4450, 1552-4469, 1552-4469
Online Access:	Get full text
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