A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor

Recent isothiocyanate covalent labeling studies have suggested that a classical cannabinoid, (-)-7'-isothiocyanato-11-hydroxy-1',1'dimethylheptyl-hexahydrocannabinol (AM841), enters the cannabinoid CB2 receptor via the lipid bilayer (Pei, Y., Mercier, R. W., Anday, J. K., Thakur, G. A...

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Vydané v:	The Journal of biological chemistry Ročník 285; číslo 23; s. 17954
Hlavní autori:	Hurst, Dow P, Grossfield, Alan, Lynch, Diane L, Feller, Scott, Romo, Tod D, Gawrisch, Klaus, Pitman, Michael C, Reggio, Patricia H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 04.06.2010
Predmet:	Animals Arachidonic Acids - chemistry Biophysics - methods Cannabinoids - chemistry Cattle Computer Simulation Eicosanoids - chemistry Endocannabinoids Glycerides - chemistry Hydrogen Bonding Ions Ligands Lipid Bilayers - chemistry Lipids - chemistry Protein Binding Receptors, G-Protein-Coupled - chemistry Rhodopsin - chemistry Solvents - chemistry
ISSN:	1083-351X, 1083-351X
On-line prístup:	Zistit podrobnosti o prístupe
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