A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor

Recent isothiocyanate covalent labeling studies have suggested that a classical cannabinoid, (-)-7'-isothiocyanato-11-hydroxy-1',1'dimethylheptyl-hexahydrocannabinol (AM841), enters the cannabinoid CB2 receptor via the lipid bilayer (Pei, Y., Mercier, R. W., Anday, J. K., Thakur, G. A...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 285; no. 23; p. 17954
Main Authors:	Hurst, Dow P, Grossfield, Alan, Lynch, Diane L, Feller, Scott, Romo, Tod D, Gawrisch, Klaus, Pitman, Michael C, Reggio, Patricia H
Format:	Journal Article
Language:	English
Published:	United States 04.06.2010
Subjects:	Animals Arachidonic Acids - chemistry Biophysics - methods Cannabinoids - chemistry Cattle Computer Simulation Eicosanoids - chemistry Endocannabinoids Glycerides - chemistry Hydrogen Bonding Ions Ligands Lipid Bilayers - chemistry Lipids - chemistry Protein Binding Receptors, G-Protein-Coupled - chemistry Rhodopsin - chemistry Solvents - chemistry
ISSN:	1083-351X, 1083-351X
Online Access:	Get more information
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