An explainable algorithm for detecting drug-induced QT-prolongation at risk of torsades de pointes (TdP) regardless of heart rate and T-wave morphology

Torsade de points (TdP), a life-threatening arrhythmia that can increase the risk of sudden cardiac death, is associated with drug-induced QT-interval prolongation on the electrocardiogram (ECG). While many modern ECG machines provide automated measurements of the QT-interval, these automated QT val...

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Bibliographic Details
Published in:	Computers in biology and medicine Vol. 131; p. 104281
Main Authors:	Alahmadi, Alaa, Davies, Alan, Royle, Jennifer, Goodwin, Leanna, Cresswell, Katharine, Arain, Zahra, Vigo, Markel, Jay, Caroline
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.04.2021 Elsevier Limited
Subjects:	Algorithms Arrhythmia Automated ECG interpretation Automation Cardiac arrhythmia Clinical trials Correlation coefficients Decision trees Drug-induced LQTS Drugs EKG Electrocardiography Explainable AI Heart rate Human-like algorithm Internal Medicine Long QT syndrome Machine perception Methods Morphology Other Pharmaceutical industry Placebos Prolongation QT-Prolongation Risk Rule-based algorithm TdP Torsades de pointes Ventricle Visual perception TdP Human-like algorithm Explainable AI Automated ECG interpretation Torsades de pointes Drug-induced LQTS Rule-based algorithm QT-Prolongation Machine perception Visual perception QT-prolongation
ISSN:	0010-4825, 1879-0534, 1879-0534
Online Access:	Get full text
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