The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington’s disease human brain

The recent demonstration of endogenous stem/progenitor cells in the adult mammalian brain raises the exciting possibility that these undifferentiated cells may be able to generate new neurons for cell replacement in neurodegenerative diseases such as Huntington’s disease (HD). Previous studies have...

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Vydané v:	Neuroscience Ročník 132; číslo 3; s. 777 - 788
Hlavní autori:	Curtis, M.A., Penney, E.B., Pearson, J., Dragunow, M., Connor, B., Faull, R.L.M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford Elsevier Ltd 2005 Elsevier
Predmet:	Aged Aged, 80 and over Biological and medical sciences caudate nucleus Cell Count - methods cell replacement therapy Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnostic Imaging Female Fundamental and applied biological sciences. Psychology Humans Huntington Disease - metabolism Huntington Disease - pathology Immunohistochemistry - methods Lateral Ventricles - pathology Male Medical sciences Middle Aged neurogenesis Neurology Neurons - metabolism Neurons - pathology Postmortem Changes proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism Stem Cells - metabolism Stem Cells - pathology subventricular zone Tubulin - metabolism Vertebrates: nervous system and sense organs caudate nucleus proliferating cell nuclear antigen EPL PBS subventricular zone cell replacement therapy PCNA neurogenesis SEL HD BrdU Human Nervous system diseases Replacement therapy Central nervous system Precursor cell Huntington disease Basal ganglion Neurogenesis Cerebral disorder Genetic disease Caudate nucleus Central nervous system disease Distribution Degenerative disease Lateral cerebral ventricle PCNA antigen Extrapyramidal syndrome Progenitor cell
ISSN:	0306-4522, 1873-7544
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