One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release

In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs- x /3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS)...

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Published in:	Nanoscale research letters Vol. 14; no. 1; pp. 259 - 12
Main Authors:	Wang, Xianshu, Pan, Hongyan, Lin, Qian, Wu, Hong, Jia, Shuangzhu, Shi, Yongyong
Format:	Journal Article
Language:	English
Published:	New York Springer US 30.07.2019 Springer Nature B.V SpringerOpen
Subjects:	Adsorption Biocompatibility Block copolymers Carbon Carbon sources Carbonization Chemistry and Materials Science Chitosan Contact angle Drug delivery carrier Drug delivery systems Drying Hydrophilicity Hydroxycamptothecin Materials Science Measuring instruments Molecular Medicine Nano Express Nanochemistry Nanoscale Science and Technology Nanotechnology Nanotechnology and Microengineering Nitrogen Nitrogen-doped mesoporous carbon spheres Pore size Pore size distribution Porosity Silicon Size distribution Spray drying Surface chemistry Tetraethoxysilane Tetraethyl orthosilicate X ray photoelectron spectroscopy Nitrogen-doped mesoporous carbon spheres Hydroxycamptothecin Chitosan Hydrophilicity Drug delivery carrier
ISSN:	1931-7573, 1556-276X
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Abstract	In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs- x /3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m 2 /g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs- x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs- x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs- x towards HCPT was in the following orders: q NMCs-5/3 > q NMCs-6/3 > q NMCs-7/3 > q NMCs-8/3 . NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g −1 ) and higher dissolution rate (93.75%).
AbstractList	In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m /g), narrowly pore size distribution (2.01-3.65 nm), and high nitrogen content (4.75-6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: q > q > q > q . NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g ) and higher dissolution rate (93.75%). In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m2/g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: qNMCs-5/3 > qNMCs-6/3 > qNMCs-7/3 > qNMCs-8/3. NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g−1) and higher dissolution rate (93.75%). In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m2/g), narrowly pore size distribution (2.01-3.65 nm), and high nitrogen content (4.75-6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: qNMCs-5/3 > qNMCs-6/3 > qNMCs-7/3 > qNMCs-8/3. NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g-1) and higher dissolution rate (93.75%).In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m2/g), narrowly pore size distribution (2.01-3.65 nm), and high nitrogen content (4.75-6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: qNMCs-5/3 > qNMCs-6/3 > qNMCs-7/3 > qNMCs-8/3. NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g-1) and higher dissolution rate (93.75%). In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs- x /3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m 2 /g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs- x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs- x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs- x towards HCPT was in the following orders: q NMCs-5/3 > q NMCs-6/3 > q NMCs-7/3 > q NMCs-8/3 . NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g −1 ) and higher dissolution rate (93.75%). In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m2/g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: qNMCs-5/3> qNMCs-6/3> qNMCs-7/3> qNMCs-8/3. NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g−1) and higher dissolution rate (93.75%). Abstract In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m2/g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: q NMCs-5/3 > q NMCs-6/3 > q NMCs-7/3 > q NMCs-8/3. NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g−1) and higher dissolution rate (93.75%).
ArticleNumber	259
Author	Shi, Yongyong Pan, Hongyan Jia, Shuangzhu Lin, Qian Wu, Hong Wang, Xianshu
Author_xml	– sequence: 1 givenname: Xianshu surname: Wang fullname: Wang, Xianshu organization: School of Chemistry and Chemical Engineering, Guizhou University, Key Laboratory of Green Chemical and Clean Energy Technology, School of Pharmacy, Guizhou University of Traditional Chinese Medicine – sequence: 2 givenname: Hongyan surname: Pan fullname: Pan, Hongyan organization: School of Chemistry and Chemical Engineering, Guizhou University, Key Laboratory of Green Chemical and Clean Energy Technology – sequence: 3 givenname: Qian surname: Lin fullname: Lin, Qian email: celinqianphy@163.com organization: School of Chemistry and Chemical Engineering, Guizhou University, Key Laboratory of Green Chemical and Clean Energy Technology – sequence: 4 givenname: Hong surname: Wu fullname: Wu, Hong organization: School of Chemistry and Chemical Engineering, Guizhou University, Key Laboratory of Green Chemical and Clean Energy Technology – sequence: 5 givenname: Shuangzhu surname: Jia fullname: Jia, Shuangzhu organization: School of Chemistry and Chemical Engineering, Guizhou University, Key Laboratory of Green Chemical and Clean Energy Technology – sequence: 6 givenname: Yongyong surname: Shi fullname: Shi, Yongyong organization: School of Chemistry and Chemical Engineering, Guizhou University, Key Laboratory of Green Chemical and Clean Energy Technology
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Copyright	The Author(s). 2019 Nanoscale Research Letters is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright Springer Nature B.V. Dec 2019
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Keywords	Nitrogen-doped mesoporous carbon spheres Hydroxycamptothecin Chitosan Hydrophilicity Drug delivery carrier
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Snippet	In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs- x /3, x = 5, 6, 7, and 8) were prepared by... In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by... Abstract In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were...
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SubjectTerms	Adsorption Biocompatibility Block copolymers Carbon Carbon sources Carbonization Chemistry and Materials Science Chitosan Contact angle Drug delivery carrier Drug delivery systems Drying Hydrophilicity Hydroxycamptothecin Materials Science Measuring instruments Molecular Medicine Nano Express Nanochemistry Nanoscale Science and Technology Nanotechnology Nanotechnology and Microengineering Nitrogen Nitrogen-doped mesoporous carbon spheres Pore size Pore size distribution Porosity Silicon Size distribution Spray drying Surface chemistry Tetraethoxysilane Tetraethyl orthosilicate X ray photoelectron spectroscopy
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Title	One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release
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