Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Charles Mullighan, Jinghui Zhang and colleagues characterize a subtype of B-progenitor acute lymphoblastic leukemia with deregulated DUX4 and ERG . They find that aberrant DUX4 activation results in loss of ERG function, either through deletion or by the induction a novel transforming ERG isoform, E...

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Published in:	Nature genetics Vol. 48; no. 12; pp. 1481 - 1489
Main Authors:	Zhang, Jinghui, McCastlain, Kelly, Yoshihara, Hiroki, Xu, Beisi, Chang, Yunchao, Churchman, Michelle L, Wu, Gang, Li, Yongjin, Wei, Lei, Iacobucci, Ilaria, Liu, Yu, Qu, Chunxu, Wen, Ji, Edmonson, Michael, Payne-Turner, Debbie, Kaufmann, Kerstin B, Takayanagi, Shin-ichiro, Wienholds, Erno, Waanders, Esmé, Ntziachristos, Panagiotis, Bakogianni, Sofia, Wang, Jingjing, Aifantis, Iannis, Roberts, Kathryn G, Ma, Jing, Song, Guangchun, Easton, John, Mulder, Heather L, Chen, Xiang, Newman, Scott, Ma, Xiaotu, Rusch, Michael, Gupta, Pankaj, Boggs, Kristy, Vadodaria, Bhavin, Dalton, James, Liu, Yanling, Valentine, Marcus L, Ding, Li, Lu, Charles, Fulton, Robert S, Fulton, Lucinda, Tabib, Yashodhan, Ochoa, Kerri, Devidas, Meenakshi, Pei, Deqing, Cheng, Cheng, Yang, Jun, Evans, William E, Relling, Mary V, Pui, Ching-Hon, Jeha, Sima, Harvey, Richard C, Chen, I-Ming L, Willman, Cheryl L, Marcucci, Guido, Bloomfield, Clara D, Kohlschmidt, Jessica, Mrózek, Krzysztof, Paietta, Elisabeth, Tallman, Martin S, Stock, Wendy, Foster, Matthew C, Racevskis, Janis, Rowe, Jacob M, Luger, Selina, Kornblau, Steven M, Shurtleff, Sheila A, Raimondi, Susana C, Mardis, Elaine R, Wilson, Richard K, Dick, John E, Hunger, Stephen P, Loh, Mignon L, Downing, James R, Mullighan, Charles G
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.12.2016 Nature Publishing Group
Subjects:	45 45/23 631/114/2785/2302 631/208/200 631/208/212/2019 631/67/1990/283/2125 692/699/67/1990/283/2125 Acute lymphocytic leukemia Adolescent Adult Agriculture Animal Genetics and Genomics Biomedicine Cancer Cancer Research Cell cycle Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Children & youth Deregulation DNA binding proteins Gene Deletion Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Function Gene Rearrangement Genes Genetic aspects Genomes Grants Homeodomain Proteins - genetics Hospitals Human Genetics Humans Leukemia Lymphoma Mutation Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Protein Isoforms Transcription (Genetics) Transcription factors Transcriptional Regulator ERG - genetics Young Adult
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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