Kindlin-3–independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III

Activation of hematopoietic integrins to a high-affinity ligand-binding conformation requires interaction with several cytoplasmic proteins, including kindlin-3.2 The importance of kindlin-3 is illustrated by leukocyte adhesion deficiency type III (LAD-III), a rare autosomal-recessive syndrome cause...

Ausführliche Beschreibung