Kindlin-3–independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III

Activation of hematopoietic integrins to a high-affinity ligand-binding conformation requires interaction with several cytoplasmic proteins, including kindlin-3.2 The importance of kindlin-3 is illustrated by leukocyte adhesion deficiency type III (LAD-III), a rare autosomal-recessive syndrome cause...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 133; no. 4; pp. 1215 - 1218.e3
Main Authors:	van de Vijver, Edith, Tool, Anton T.J., Sanal, Özden, Çetin, Mualla, Ünal, Sule, Aytac, Selin, Seeger, Karl, Pagliara, Daria, Rutella, Sergio, van den Berg, Timo K., Kuijpers, Taco W.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01.04.2014 Elsevier Elsevier Limited
Subjects:	Allergy and Immunology Biological and medical sciences Cell Adhesion - drug effects Cell Adhesion - genetics Cell Adhesion - immunology Cloning Fundamental and applied biological sciences. Psychology Fundamental immunology Hematologic and hematopoietic diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Kinases Leukocyte-Adhesion Deficiency Syndrome - diagnosis Leukocyte-Adhesion Deficiency Syndrome - genetics Leukocyte-Adhesion Deficiency Syndrome - metabolism Ligands Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Other diseases. Hematologic involvement in other diseases Patients Phosphates Proteins Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Human Immunopathology Immunology Hemopathy Neutrophil Immune deficiency Adhesion Leukocyte adhesion deficiency Leukocyte disease Genetic disease
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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