p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit extracellular signals to regulate cell growth, proliferation, differentiation, migration, apoptosis and so on. Apoptosis as well as macr...

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Published in:Cancer letters Vol. 344; no. 2; pp. 174 - 179
Main Authors: Sui, Xinbing, Kong, Na, Ye, Li, Han, Weidong, Zhou, Jichun, Zhang, Qin, He, Chao, Pan, Hongming
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 28.03.2014
Elsevier Limited
Subjects:
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Autophagy
Autophagy - drug effects
Autophagy - physiology
Cancer
Cancer therapies
Chemoresistance
Hematology, Oncology and Palliative Medicine
Humans
JNK
Kinases
MAP Kinase Kinase 4 - metabolism
MAP Kinase Signaling System - drug effects
MAP Kinase Signaling System - physiology
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - pathology
P38
p38 Mitogen-Activated Protein Kinases - metabolism
P38
Autophagy
JNK
Chemoresistance
Apoptosis
ISSN:0304-3835, 1872-7980, 1872-7980
Online Access:Get full text
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Summary:The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit extracellular signals to regulate cell growth, proliferation, differentiation, migration, apoptosis and so on. Apoptosis as well as macroautophagy (hereafter referred to as autophagy) can be induced by extracellular stimuli such the treatment of chemotherapeutic agents, resulting in different cell response to these drugs. However, the molecular mechanisms mediating these two cellular processes remain largely unknown. Recently, several studies provide new insights into p38 and JNK MAPK pathways function in the control of the balance of autophagy and apoptosis in response to genotoxic stress. Our increased understanding of the role of p38 and JNK MAPK pathways in regulating the balance of autophagy and apoptosis will hopefully provide prospective strategies for cancer therapy.
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ISSN:0304-3835
1872-7980
1872-7980
DOI:10.1016/j.canlet.2013.11.019