Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR

Recurrent, reciprocal genomic disorders due to non-allelic homologous recombination (NAHR) are a major cause of human disease. The authors developed a CRISPR/Cas9 genome engineering method that directly targets segmental duplications and efficiently mimics the NAHR-mediated mechanism of microdeletio...

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Vydáno v:	Nature neuroscience Ročník 19; číslo 3; s. 517 - 522
Hlavní autoři:	Tai, Derek J C, Ragavendran, Ashok, Manavalan, Poornima, Stortchevoi, Alexei, Seabra, Catarina M, Erdin, Serkan, Collins, Ryan L, Blumenthal, Ian, Chen, Xiaoli, Shen, Yiping, Sahin, Mustafa, Zhang, Chengsheng, Lee, Charles, Gusella, James F, Talkowski, Michael E
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.03.2016 Nature Publishing Group
Témata:	13/1 13/100 13/109 45/23 45/77 45/90 45/91 631/1647/1511 631/1647/767/722 631/61/338 Animal Genetics and Genomics Autistic Disorder - genetics Behavioral Sciences Biological Techniques Biomedicine Chromosome Deletion Chromosome Disorders - genetics Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 16 - genetics Clustered Regularly Interspaced Short Palindromic Repeats - genetics Copy number variations CRISPR CRISPR-Cas Systems - genetics DNA Copy Number Variations - genetics Engineering Genetic engineering Genetic Engineering - methods Genetic research Genetic screening Genomes Hospitals Humans Identification and classification Innovations Intellectual Disability - genetics Laboratories Methods Mutation Neurobiology Neurosciences Proteins Segmental Duplications, Genomic - genetics Seizures - genetics Sequence Deletion - genetics technical-report United States > US Massachusetts
ISSN:	1097-6256, 1546-1726, 1546-1726
On-line přístup:	Získat plný text
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