Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

Objectives: Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus. This study investigated the mechanism of triptolide (TP) in podocyte injury in DN. Methods: DN mouse models were established by feeding with a high-fat diet and injecting with streptozocin and M...

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Bibliographic Details
Published in:	Renal failure Vol. 45; no. 1; p. 2165103
Main Authors:	Lv, Chenlei, Cheng, Tianyang, Zhang, Bingbing, Sun, Ke, Lu, Keda
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01.12.2023 Taylor & Francis Ltd Taylor & Francis Group
Subjects:	Animal models Animals Apoptosis Body weight Cell viability Clinical Study Creatinine Diabetes Diabetes Mellitus Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic Nephropathies - prevention & control Diabetic nephropathy Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism High fat diet Inflammasomes Inflammasomes - metabolism Inflammasomes - pharmacology Inflammation Mice Microvasculature MPC5 Nephropathy NF-E2-Related Factor 2 - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Nrf2 Oxidative stress Podocytes - pathology Pyrin protein Pyroptosis Reactive oxygen species Reactive Oxygen Species - metabolism Renal function Streptozocin Triptolide Western blotting MPC5 Diabetic nephropathy triptolide NLRP3 inflammasome Nrf2 oxidative stress
ISSN:	0886-022X, 1525-6049, 1525-6049
Online Access:	Get full text
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