ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair processes at stalled or converging replication forks. Recent...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 24; H. 10; S. 2629 - 2642.e5
Hauptverfasser:	Mutreja, Karun, Krietsch, Jana, Hess, Jeannine, Ursich, Sebastian, Berti, Matteo, Roessler, Fabienne K., Zellweger, Ralph, Patra, Malay, Gasser, Gilles, Lopes, Massimo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 04.09.2018 Cell Press Elsevier
Schlagworte:	ATR checkpoint Chemical Sciences DNA interstrand crosslinks DNA replication DNA replication stress response electron microscopy fork traverse global fork slowing ICL immunolabeling Medicinal Chemistry replication fork reversal DNA replication stress response DNA replication fork traverse electron microscopy ATR checkpoint replication fork reversal global fork slowing DNA interstrand crosslinks ICL immunolabeling
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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