Stress, sex hormones, inflammation, and major depressive disorder: Extending Social Signal Transduction Theory of Depression to account for sex differences in mood disorders

Social Signal Transduction Theory of Depression is a biologically plausible, multi-level theory that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental adversity with internal biological processes that drive depression pathogenesis, mainten...

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Vydáno v:	Psychopharmacology Ročník 236; číslo 10; s. 3063 - 3079
Hlavní autoři:	Slavich, George M., Sacher, Julia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019 Springer Springer Nature B.V
Témata:	Analysis Anxiety Arthritis Asthma Biomedical and Life Sciences Biomedicine Brain - immunology Cardiovascular diseases Cellular signal transduction Chronic pain Depressive Disorder, Major - diagnosis Depressive Disorder, Major - immunology Depressive Disorder, Major - psychology Female Functional anatomy Gender differences Gonadal Steroid Hormones - immunology Hedonic response Hormones Hormones, Sex Humans Inflammation Inflammation - diagnosis Inflammation - immunology Inflammation - psychology Intellectual disabilities Male Mental depression Mental disorders Mood Mood disorders Mood Disorders - diagnosis Mood Disorders - immunology Mood Disorders - psychology Nervous system diseases Neurodegenerative diseases Neurodevelopmental disorders Neurosciences Pain Pharmacology/Toxicology Psychiatry Review Rheumatoid arthritis Rheumatoid factor Sex Characteristics Sex differences Sex differences (Psychology) Sex hormones Signal transduction Signal Transduction - physiology Stress (Psychology) Stress, Psychological - diagnosis Stress, Psychological - immunology Stress, Psychological - psychology Structure-function relationships Withdrawal Women New York Canada Sex hormones Life stress Cytokines Disease Sex differences Neuroinflammation Risk Depression Social threat Inflammation
ISSN:	0033-3158, 1432-2072, 1432-2072
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Shrnutí:	Social Signal Transduction Theory of Depression is a biologically plausible, multi-level theory that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental adversity with internal biological processes that drive depression pathogenesis, maintenance, and recurrence. Central to this theory is the hypothesis that interpersonal stressors involving social threat (e.g., social conflict, evaluation, rejection, isolation, and exclusion) upregulate inflammatory processes that can induce several depressive symptoms, including sad mood, anhedonia, fatigue, psychomotor retardation, and social-behavioral withdrawal. The original article describing this formulation (Psychol Bull 140:774–815, 2014) addressed critical questions involving depression onset and recurrence, as well as why depression is strongly predicted by early life stress and comorbid with anxiety disorders and certain physical disease conditions, such as asthma, rheumatoid arthritis, chronic pain, and cardiovascular disease. Here, we extend the theory to help explain sex differences in depression prevalence, which is a defining feature of this disorder. Central to this extension is research demonstrating that ovarian hormone fluctuations modulate women’s susceptibility to stress, brain structure and function, and inflammatory activity and reactivity. These effects are evident at multiple levels and are highly context-dependent, varying as a function of several factors including sex, age, reproductive state, endogenous versus exogenous hormones, and hormone administration mode and dose. Together, these effects help explain why women are at greater risk for developing inflammation-related depressed mood and other neuropsychiatric, neurodevelopmental, and neurodegenerative disorders during the reproductive years, especially for those already at heightened risk for depression or in the midst of a hormonal transition period.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
ISSN:	0033-3158 1432-2072 1432-2072
DOI:	10.1007/s00213-019-05326-9