Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis

Objectives: Acute kidney injury (AKI) is associated with increased mortality among coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk factors for the development of AKI in patients with COVID-19. Methods: A systematic literature search was conducted in PubMed and...

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Veröffentlicht in:Renal failure Jg. 45; H. 1; S. 2170809
Hauptverfasser: Zhang, Jialing, Pang, Qi, Zhou, Ting, Meng, Jiali, Dong, Xingtong, Wang, Zhe, Zhang, Aihua
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Taylor & Francis 01.12.2023
Taylor & Francis Ltd
Taylor & Francis Group
Schlagworte:
Acute kidney injury
Acute Kidney Injury - etiology
Comorbidity
Congestive heart failure
Coronaviruses
COVID-19
COVID-19 - complications
Diabetes mellitus
Diuretics
Humans
Kidney diseases
Kidneys
Male
Meta-analysis
Prognosis
Regression analysis
Renal failure
Renal Insufficiency, Chronic - complications
Respiratory distress syndrome
Review
Risk Factors
Sensitivity analysis
State-of-the-Art Review
Steroid hormones
systematic review
COVID-19
meta-analysis
systematic review
Acute kidney injury
ISSN:0886-022X, 1525-6049, 1525-6049
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Zusammenfassung:Objectives: Acute kidney injury (AKI) is associated with increased mortality among coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk factors for the development of AKI in patients with COVID-19. Methods: A systematic literature search was conducted in PubMed and EMBASE from 1 December 2019 to 1 January 2023. Due to significant study heterogeneity, meta-analyses were conducted using random-effects models. Meta-regression and sensitivity analysis were also performed. Results: A total of 153,600 COVID-19 patients from 39 studies were included, and 28,003 patients developed AKI. By meta-analysis, we discovered that age, male sex, obesity, black race, invasive ventilation, and the use of diuretics, steroids and vasopressors, in addition to comorbidities such as hypertension, congestive heart failure, chronic kidney disease, acute respiratory distress syndrome, and diabetes, were significant risk factors for COVID-19-associated AKI. Conclusions: Early detection of these risk factors is essential to reduce the incidence of AKI and improve the prognosis of COVID-19 patients.
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Supplemental data for this article can be accessed online at https://doi.org/10.1080/0886022X.2023.2170809.
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2023.2170809