Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition

Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in theory, more likely to be relevant. Because pyro...

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Vydáno v:	Blood Ročník 130; číslo 24; s. 2664
Hlavní autoři:	Nazir, Sumra, Gadi, Ihsan, Al-Dabet, Moh'd Mohanad, Elwakiel, Ahmed, Kohli, Shrey, Ghosh, Sanchita, Manoharan, Jayakumar, Ranjan, Satish, Bock, Fabian, Braun-Dullaeus, Ruediger C, Esmon, Charles T, Huber, Tobias B, Camerer, Eric, Dockendorff, Chris, Griffin, John H, Isermann, Berend, Shahzad, Khurrum
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 14.12.2017
Témata:	Animals Animals, Newborn Anticoagulants - pharmacology Apoptosis - drug effects Cells, Cultured Cytoprotection - drug effects Cytoprotection - genetics Immunoblotting Inflammasomes - drug effects Inflammasomes - metabolism Kidney - blood supply Kidney - drug effects Kidney - metabolism Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors Mechanistic Target of Rapamycin Complex 1 - metabolism Mice, Inbred C57BL Mice, Knockout Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Protective Agents - pharmacology Protein C - pharmacology Receptor, PAR-1 - genetics Receptor, PAR-1 - metabolism Reperfusion Injury - metabolism Reperfusion Injury - prevention & control
ISSN:	1528-0020, 1528-0020
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