PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induc...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 16; no. 9; pp. 2415 - 2427
Main Authors:	Missiroli, Sonia, Bonora, Massimo, Patergnani, Simone, Poletti, Federica, Perrone, Mariasole, Gafà, Roberta, Magri, Eros, Raimondi, Andrea, Lanza, Giovanni, Tacchetti, Carlo, Kroemer, Guido, Pandolfi, Pier Paolo, Pinton, Paolo, Giorgi, Carlotta
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 30.08.2016 Cell Press Elsevier
Subjects:	Adenine - analogs & derivatives Adenine - pharmacology Animals Antineoplastic Agents - pharmacology Arsenic Trioxide Arsenicals - pharmacology Autophagy - drug effects Autophagy - genetics Calcium - metabolism Cancer Cell Line, Tumor Disease Progression Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation, Neoplastic Humans Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Leukemia, Promyelocytic, Acute - pathology Life Sciences Membrane Potential, Mitochondrial - drug effects Mice Mice, Knockout Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membranes - drug effects Mitochondrial Membranes - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oxides - pharmacology Promyelocytic Leukemia Protein - deficiency Promyelocytic Leukemia Protein - genetics Promyelocytic Leukemia Protein - metabolism Signal Transduction Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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