Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

Using effect estimates from genome-wide association studies (GWAS), we identified a genetic risk score (GRS) that has the strongest association with type 2 diabetes (T2D) status in a population-based cohort and investigated its potential for prospective T2D risk assessment. By varying the number of...

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Bibliographic Details
Published in:	Genetics in medicine Vol. 19; no. 3; pp. 322 - 329
Main Authors:	Läll, Kristi, Mägi, Reedik, Morris, Andrew, Metspalu, Andres, Fischer, Krista
Format:	Journal Article
Language:	English
Published:	New York Elsevier Inc 01.03.2017 Nature Publishing Group US Elsevier Limited Nature Publishing Group
Subjects:	631/208/205/2138 631/208/2489/144 631/208/727/2000 692/699/2743/137/773 Alleles Biomedical and Life Sciences Biomedicine Body Mass Index Cohort Studies Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - prevention & control Diabetes Mellitus, Type 2 - therapy Female Genetic Predisposition to Disease genetic risk genetic risk score Genetic Testing - methods Genome-Wide Association Study Genotype Human Genetics Humans Laboratory Medicine Male Middle Aged Original original-research-article Polymorphism, Single Nucleotide precision medicine Precision Medicine - methods Prospective Studies Risk Factors risk prediction type 2 diabetes genetic risk score precision medicine type 2 diabetes risk prediction genetic risk
ISSN:	1098-3600, 1530-0366, 1530-0366
Online Access:	Get full text
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