Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study

Background Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its imp...

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Published in:Allergy (Copenhagen) Vol. 73; no. 8; pp. 1622 - 1631
Main Authors: Bousquet, J., Devillier, P., Anto, J. M., Bewick, M., Haahtela, T., Arnavielhe, S., Bedbrook, A., Murray, R., van Eerd, M., Fonseca, J. A., Morais Almeida, M., Todo Bom, A., Menditto, E., Passalacqua, G., Stellato, C., Triggiani, M., Ventura, M. T., Vezzani, G., Annesi‐Maesano, I., Bourret, R., Bosse, I., Caimmi, D., Cartier, C., Demoly, P., Just, J., Portejoie, F., Siroux, V., Viart, F., Bergmann, K. C., Keil, T., Klimek, L., Mösges, R., Pfaar, O., Shamai, S., Zuberbier, T., Mullol, J., Valero, A., Spranger, O., Tomazic, P. V., Kowalski, M. L., Kuna, P., Kupczyk, M., Raciborski, F., Samolinski, B., Toppila‐Salmi, S. K., Valovirta, E., Cruz, A. A., Sarquis‐Serpa, F., Silva, J., Stelmach, R., Larenas‐Linnemann, D., Rodriguez Gonzalez, M., Burguete Cabañas, M. T., Kvedariene, V., Valiulis, A., Chavannes, N. H., Fokkens, W. J., Ryan, D., Sheikh, A., Bachert, C., Hellings, P. W., VandenPlas, O., Ballardini, N., Kull, I., Melén, E., Westman, M., Wickman, M., Bindslev‐Jensen, C., Eller, E., Bosnic‐Anticevich, S., O'Hehir, R. E., Agache, I., Bieber, T., Casale, T., Gemicioğlu, B., Ivancevich, J. C., De Vries, G., Sorensen, M., Yorgancioglu, A., Laune, D.
Format: Journal Article
Language:English
Published: Denmark Blackwell Publishing Ltd 01.08.2018
Wiley
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Allergies
Allergology
Asthma
Child
Comorbidity
Conjunctivitis
Female
Humans
Hypersensitivity - epidemiology
Immunology
Life Sciences
Male
Middle Aged
Mobile Applications
Multimorbidity
Nose
Patient Outcome Assessment
Portable computers
Prevalence
Productivity
Prospective Studies
Research Design
Respiratory tract diseases
Rhinitis
Rhinitis - epidemiology
work productivity
Young Adult
multimorbidity
asthma
rhinitis
work productivity
conjunctivitis
ISSN:0105-4538, 1398-9995, 1398-9995
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Summary:Background Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods We undertook a 1‐year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis‐driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions In a novel approach examining daily symptoms with mobile technology, we found considerable intra‐individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.
Bibliography:Funding information
The study has been funded by an unrestricted educational grant from Meda, the Fondation Partenariale FMC VIA LR and Structural and Development Funds from the EU (Région Languedoc Roussillon).
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ISSN:0105-4538
1398-9995
1398-9995
DOI:10.1111/all.13448