Some Alternatives to Asymptotic Tests for the Analysis of Pharmacogenetic Data Using Nonlinear Mixed Effects Models

Nonlinear mixed effects models allow investigating individual differences in drug concentration profiles (pharmacokinetics) and responses. Pharmacogenetics focuses on the genetic component of this variability. Two tests often used to detect a gene effect on a pharmacokinetic parameter are (1) the Wa...

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Bibliographic Details
Published in:	Biometrics Vol. 68; no. 1; pp. 146 - 155
Main Authors:	Bertrand, Julie, Comets, Emmanuelle, Chenel, Marylore, Mentré, France
Format:	Journal Article
Language:	English
Published:	Malden, USA Blackwell Publishing Inc 01.03.2012 Wiley-Blackwell Blackwell Publishing Ltd
Subjects:	algorithms Asymptotic methods BIOMETRIC METHODOLOGY Biometrics biometry Biometry - methods Computer Simulation Data Interpretation, Statistical Datasets Drug design drugs Estimating techniques F-distribution-based approach First-order approximation genes Genetics genotype Humans Mathematical vectors Modeling Models, Statistical Nonlinear Dynamics Nonlinear mixed effects models P values Parametric models patients Permutation tests Pharmacogenetics Pharmacogenetics - methods Pharmacogenetics - statistics & numerical data pharmacogenomics Pharmacokinetics Pharmacology Statistical variance statistics
ISSN:	0006-341X, 1541-0420, 1541-0420
Online Access:	Get full text
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